K273-0163 Screening compound: 17-[(Z,2E)-1-hydroxy-3-(4-methylphenyl)-2-propenylidene]-15-methyl-2-oxa-15-azatetracyclo[7.5.3.0~1,10~.0~3,8~]heptadeca-3,5,7-trien-16-one

K273-0163 Screening compound: 17-[(Z,2E)-1-hydroxy-3-(4-methylphenyl)-2-propenylidene]-15-methyl-2-oxa-15-azatetracyclo[7.5.3.0~1,10~.0~3,8~]heptadeca-3,5,7-trien-16-one
K273-0163 Screening compound: 17-[(Z,2E)-1-hydroxy-3-(4-methylphenyl)-2-propenylidene]-15-methyl-2-oxa-15-azatetracyclo[7.5.3.0~1,10~.0~3,8~]heptadeca-3,5,7-trien-16-one alternative view

Chemical Structure Depiction of ChemDiv screening compound K273-0163
17-[(Z,2E)-1-hydroxy-3-(4-methylphenyl)-2-propenylidene]-15-methyl-2-oxa-15-azatetracyclo[7.5.3.0~1,10~.0~3,8~]heptadeca-3,5,7-trien-16-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

K273-0163

Molecular Formula

C26H27NO3 (C26 H27 NO3)

Compound Name

17-[(Z,2E)-1-hydroxy-3-(4-methylphenyl)-2-propenylidene]-15-methyl-2-oxa-15-azatetracyclo[7.5.3.0~1,10~.0~3,8~]heptadeca-3,5,7-trien-16-one

IUPAC name

(17Z)-17-[(2E)-1-hydroxy-3-(4-methylphenyl)prop-2-en-1-ylidene]-15-methyl-2-oxa-15-azatetracyclo[7.5.3.0^{110}.0^{38}]heptadeca-357-trien-16-one

SMILES

Cc1ccc(/C=C/C(/O)=C(\C(C2CCCC3)c(cccc4)c4OC23N2C)/C2=O)cc1

InChI

InChI=1S/C26H27NO3/c1-17-10-12-18(13-11-17)14-15-21(28)24-23-19-7-3-4-9-22(19)30-26(27(2)25(24)29)16-6-5-8-20(23)26/h3-4,7,9-15,20,23,28H,5-6,8,16H2,1-2H3

InChI Key

SLBBDXOOZOXXIK-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD05032621

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

401.51

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

2.00

Number of Nitrogen and Oxygen Atoms

4

Partition Coefficient, logP

5.138

Distribution Coefficient, logD

5.138

Water Solubility, LogSw

-4.90

Polar Surface Area

38.789

Acid Dissociation Constant (pKa)

11.80

Base Dissociation Constant (pKb)

-0.61

Number of Chiral Centers

3.00

Percent sp3 carbon bonding

34.60

K273-0163 in Drug Discovery

Included in Screening Libraries

DGK Inhibitors Library (10558 compounds)

Eccentric PPI Library (11937 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Protein-Protein Interaction Library (218420 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Hemic and lymphatic
  • Skin
  • Metabolic
  • Immune system
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • Kinases
Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Cyclic compounds

References: we are preparing a list of scientific research reports with K273-0163 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound K273-0163?
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What is the minimum amount of K273-0163 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for K273-0163
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for K273-0163
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of K273-0163 available by request