K286-2157 Screening compound: 3-(5-chloro-2-methoxyphenyl)-6-(4-fluorophenyl)-5-{[(oxolan-2-yl)methyl]sulfanyl}-2-sulfanylidene-2H,3H,6H,7H-[1,3]thiazolo[4,5-d]pyrimidin-7-one

K286-2157 Screening compound: 3-(5-chloro-2-methoxyphenyl)-6-(4-fluorophenyl)-5-{[(oxolan-2-yl)methyl]sulfanyl}-2-sulfanylidene-2H,3H,6H,7H-[1,3]thiazolo[4,5-d]pyrimidin-7-one
K286-2157 Screening compound: 3-(5-chloro-2-methoxyphenyl)-6-(4-fluorophenyl)-5-{[(oxolan-2-yl)methyl]sulfanyl}-2-sulfanylidene-2H,3H,6H,7H-[1,3]thiazolo[4,5-d]pyrimidin-7-one alternative view

Chemical Structure Depiction of ChemDiv screening compound K286-2157
3-(5-chloro-2-methoxyphenyl)-6-(4-fluorophenyl)-5-{[(oxolan-2-yl)methyl]sulfanyl}-2-sulfanylidene-2H,3H,6H,7H-[1,3]thiazolo[4,5-d]pyrimidin-7-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

K286-2157

Molecular Formula

C23H19ClFN3O3S3 (C23 H19 ClFN3 O3 S3)

Compound Name

3-(5-chloro-2-methoxyphenyl)-6-(4-fluorophenyl)-5-{[(oxolan-2-yl)methyl]sulfanyl}-2-sulfanylidene-2H,3H,6H,7H-[1,3]thiazolo[4,5-d]pyrimidin-7-one

IUPAC name

3-(5-chloro-2-methoxyphenyl)-6-(4-fluorophenyl)-5-{[(oxolan-2-yl)methyl]sulfanyl}-2-sulfanylidene-2H3H6H7H-[13]thiazolo[45-d]pyrimidin-7-one

SMILES

COc(ccc(Cl)c1)c1N(C(N=C(N(c(cc1)ccc1F)C1=O)SCC2OCCC2)=C1S1)C1=S

InChI

InChI=1S/C23H19ClFN3O3S3/c1-30-18-9-4-13(24)11-17(18)28-20-19(34-23(28)32)21(29)27(15-7-5-14(25)6-8-15)22(26-20)33-12-16-3-2-10-31-16/h4-9,11,16H,2-3,10,12H2,1H3/t16-/m1/s1

InChI Key

PTJPKFXGSOJZGJ-MRXNPFEDSA-N

MDL Number (MFCD)

MFCD15090381

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

536.07

Hydrogen Bond Acceptors Count

9.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

4.640

Distribution Coefficient, logD

4.640

Water Solubility, LogSw

-4.85

Polar Surface Area

42.938

Acid Dissociation Constant (pKa)

26.64

Base Dissociation Constant (pKb)

0.51

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

26.10

K286-2157 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

C-Met Library (15277 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Endocrine
Targets:
  • Kinases
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with K286-2157 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound K286-2157?
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What is the minimum amount of K286-2157 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for K286-2157
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for K286-2157
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of K286-2157 available by request