K623-0284 Screening compound: 5-bromo-N~2~-[5-[(5-chloro-2,4-dimethoxyanilino)carbonyl]-2-(6-oxo-7,11-diazatricyclo[7.3.1.0~2,7~]trideca-2,4-dien-11-yl)phenyl]-2-furamide

K623-0284 Screening compound: 5-bromo-N~2~-[5-[(5-chloro-2,4-dimethoxyanilino)carbonyl]-2-(6-oxo-7,11-diazatricyclo[7.3.1.0~2,7~]trideca-2,4-dien-11-yl)phenyl]-2-furamide
K623-0284 Screening compound: 5-bromo-N~2~-[5-[(5-chloro-2,4-dimethoxyanilino)carbonyl]-2-(6-oxo-7,11-diazatricyclo[7.3.1.0~2,7~]trideca-2,4-dien-11-yl)phenyl]-2-furamide alternative view

Chemical Structure Depiction of ChemDiv screening compound K623-0284
5-bromo-N~2~-[5-[(5-chloro-2,4-dimethoxyanilino)carbonyl]-2-(6-oxo-7,11-diazatricyclo[7.3.1.0~2,7~]trideca-2,4-dien-11-yl)phenyl]-2-furamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

K623-0284

Molecular Formula

C31H28BrClN4O6 (C31 H28 BrClN4 O6)

Compound Name

5-bromo-N~2~-[5-[(5-chloro-2,4-dimethoxyanilino)carbonyl]-2-(6-oxo-7,11-diazatricyclo[7.3.1.0~2,7~]trideca-2,4-dien-11-yl)phenyl]-2-furamide

IUPAC name

5-bromo-N-{5-[(5-chloro-24-dimethoxyphenyl)carbamoyl]-2-{6-oxo-711-diazatricyclo[7.3.1.0^{27}]trideca-24-dien-11-yl}phenyl}furan-2-carboxamide

SMILES

COc(cc(c(Cl)c1)OC)c1NC(c(cc1)cc(NC(c(o2)ccc2Br)=O)c1N(CC(C1)CN23)CC1C3=CC=CC2=O)=O

InChI

InChI=1S/C31H28BrClN4O6/c1-41-26-13-27(42-2)22(12-20(26)33)35-30(39)18-6-7-24(21(11-18)34-31(40)25-8-9-28(32)43-25)36-14-17-10-19(16-36)23-4-3-5-29(38)37(23)15-17/h3-9,11-13,17,19H,10,14-16H2,1-2H3,(H,34,40)(H,35,39)

InChI Key

WMNGEEZCNBAKPF-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15093378

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

667.94

Hydrogen Bond Acceptors Count

9.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

9.00

Number of Nitrogen and Oxygen Atoms

10

Partition Coefficient, logP

5.877

Distribution Coefficient, logD

4.154

Water Solubility, LogSw

-6.09

Polar Surface Area

88.062

Acid Dissociation Constant (pKa)

5.69

Base Dissociation Constant (pKb)

0.32

Number of Chiral Centers

2.00

Percent sp3 carbon bonding

25.80

K623-0284 in Drug Discovery

Included in Screening Libraries

Protein-Protein Interaction Library (218420 compounds)

Spiro Library (21655 compounds)

Aurora A-B Kinases Targeted Library (9426 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Cyclic compounds
  • Cyclic compounds
Therapeutical areas:
  • Cancer
  • Digestive system
  • Male
  • Female
  • Hemic and lymphatic
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with K623-0284 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound K623-0284?
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What is the minimum amount of K623-0284 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for K623-0284
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for K623-0284
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of K623-0284 available by request