L278-0397 Screening compound: N,N,1-trimethyl-2-[(N-methyl3-chloro-4-fluorobenzenesulfonamido)methyl]-1H-1,3-benzodiazole-5-carboxamide

L278-0397 Screening compound: N,N,1-trimethyl-2-[(N-methyl3-chloro-4-fluorobenzenesulfonamido)methyl]-1H-1,3-benzodiazole-5-carboxamide
L278-0397 Screening compound: N,N,1-trimethyl-2-[(N-methyl3-chloro-4-fluorobenzenesulfonamido)methyl]-1H-1,3-benzodiazole-5-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L278-0397
N,N,1-trimethyl-2-[(N-methyl3-chloro-4-fluorobenzenesulfonamido)methyl]-1H-1,3-benzodiazole-5-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L278-0397

Molecular Formula

C19H20ClFN4O3S (C19 H20 ClFN4 O3 S)

Compound Name

N,N,1-trimethyl-2-[(N-methyl3-chloro-4-fluorobenzenesulfonamido)methyl]-1H-1,3-benzodiazole-5-carboxamide

IUPAC name

NN1-trimethyl-2-[(N-methyl3-chloro-4-fluorobenzenesulfonamido)methyl]-1H-13-benzodiazole-5-carboxamide

SMILES

CN(C)C(c(cc1)cc2c1n(C)c(CN(C)S(c(cc1)cc(Cl)c1F)(=O)=O)n2)=O

InChI

InChI=1S/C19H20ClFN4O3S/c1-23(2)19(26)12-5-8-17-16(9-12)22-18(25(17)4)11-24(3)29(27,28)13-6-7-15(21)14(20)10-13/h5-10H,11H2,1-4H3

InChI Key

ZADNXXIIUCQFCD-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27239355

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

438.91

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

1.781

Distribution Coefficient, logD

1.681

Water Solubility, LogSw

-3.09

Polar Surface Area

60.790

Acid Dissociation Constant (pKa)

26.49

Base Dissociation Constant (pKb)

6.82

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

26.30

L278-0397 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

KRAS-Targeted Library (16000 compounds)

Epigenetics Focused Set (26518 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with L278-0397 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L278-0397?
Check Price and Availability of L278-0397, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L278-0397 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L278-0397
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L278-0397
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L278-0397 available by request