L282-0208 Screening compound: 3-[4-({6-ethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]-1-[(4-fluorophenyl)methyl]urea

L282-0208 Screening compound: 3-[4-({6-ethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]-1-[(4-fluorophenyl)methyl]urea
L282-0208 Screening compound: 3-[4-({6-ethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]-1-[(4-fluorophenyl)methyl]urea alternative view

Chemical Structure Depiction of ChemDiv screening compound L282-0208
3-[4-({6-ethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]-1-[(4-fluorophenyl)methyl]urea

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L282-0208

Molecular Formula

C22H21FN6OS (C22 H21 FN6 OS)

Compound Name

3-[4-({6-ethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]-1-[(4-fluorophenyl)methyl]urea

IUPAC name

3-[4-({6-ethyl-5-methyl-[124]triazolo[15-a]pyrimidin-7-yl}sulfanyl)phenyl]-1-[(4-fluorophenyl)methyl]urea

SMILES

CCc(c(C)nc1ncnn11)c1Sc(cc1)ccc1NC(NCc(cc1)ccc1F)=O

InChI

InChI=1S/C22H21FN6OS/c1-3-19-14(2)27-21-25-13-26-29(21)20(19)31-18-10-8-17(9-11-18)28-22(30)24-12-15-4-6-16(23)7-5-15/h4-11,13H,3,12H2,1-2H3,(H2,24,28,30)

InChI Key

ISIXBPLOTWXJCK-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27239665

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

436.51

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

4.259

Distribution Coefficient, logD

4.259

Water Solubility, LogSw

-4.23

Polar Surface Area

65.921

Acid Dissociation Constant (pKa)

13.70

Base Dissociation Constant (pKb)

3.71

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

18.20

L282-0208 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

C-Met Library (15277 compounds)

Serine Proteases Inhibitors Library (32732 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Endocrine
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Cardiovascular
  • Skin
  • Metabolic
  • Immune system
Targets:
  • Kinases
  • Proteases
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with L282-0208 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L282-0208?
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What is the minimum amount of L282-0208 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L282-0208
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L282-0208
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L282-0208 available by request