L327-4511 Screening compound: N-cyclopentyl-6-(4-methylphenyl)-2-[4-(pyridine-2-carbonyl)piperazin-1-yl]imidazo[2,1-b][1,3,4]thiadiazol-5-amine

L327-4511 Screening compound: N-cyclopentyl-6-(4-methylphenyl)-2-[4-(pyridine-2-carbonyl)piperazin-1-yl]imidazo[2,1-b][1,3,4]thiadiazol-5-amine
L327-4511 Screening compound: N-cyclopentyl-6-(4-methylphenyl)-2-[4-(pyridine-2-carbonyl)piperazin-1-yl]imidazo[2,1-b][1,3,4]thiadiazol-5-amine alternative view

Chemical Structure Depiction of ChemDiv screening compound L327-4511
N-cyclopentyl-6-(4-methylphenyl)-2-[4-(pyridine-2-carbonyl)piperazin-1-yl]imidazo[2,1-b][1,3,4]thiadiazol-5-amine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L327-4511

Molecular Formula

C26H29N7OS (C26 H29 N7 OS)

Compound Name

N-cyclopentyl-6-(4-methylphenyl)-2-[4-(pyridine-2-carbonyl)piperazin-1-yl]imidazo[2,1-b][1,3,4]thiadiazol-5-amine

IUPAC name

N-cyclopentyl-6-(4-methylphenyl)-2-[4-(pyridine-2-carbonyl)piperazin-1-yl]imidazo[21-b][134]thiadiazol-5-amine

SMILES

Cc(cc1)ccc1-c1c(NC2CCCC2)n2nc(N(CC3)CCN3C(c3ncccc3)=O)sc2n1

InChI

InChI=1S/C26H29N7OS/c1-18-9-11-19(12-10-18)22-23(28-20-6-2-3-7-20)33-25(29-22)35-26(30-33)32-16-14-31(15-17-32)24(34)21-8-4-5-13-27-21/h4-5,8-13,20,28H,2-3,6-7,14-17H2,1H3

InChI Key

PREHNRHYNAQXGO-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27245858

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

487.63

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

4.475

Distribution Coefficient, logD

4.474

Water Solubility, LogSw

-4.17

Polar Surface Area

60.280

Acid Dissociation Constant (pKa)

23.04

Base Dissociation Constant (pKb)

4.91

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

38.50

L327-4511 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with L327-4511 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L327-4511?
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What is the minimum amount of L327-4511 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L327-4511
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L327-4511
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L327-4511 available by request