L329-0490 Screening compound: 6-[4-(3,4-dimethoxybenzoyl)-1,4-diazepan-1-yl]-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

L329-0490 Screening compound: 6-[4-(3,4-dimethoxybenzoyl)-1,4-diazepan-1-yl]-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
L329-0490 Screening compound: 6-[4-(3,4-dimethoxybenzoyl)-1,4-diazepan-1-yl]-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione alternative view

Chemical Structure Depiction of ChemDiv screening compound L329-0490
6-[4-(3,4-dimethoxybenzoyl)-1,4-diazepan-1-yl]-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L329-0490

Molecular Formula

C20H26N4O5 (C20 H26 N4 O5)

Compound Name

6-[4-(3,4-dimethoxybenzoyl)-1,4-diazepan-1-yl]-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

IUPAC name

6-[4-(34-dimethoxybenzoyl)-14-diazepan-1-yl]-13-dimethyl-1234-tetrahydropyrimidine-24-dione

SMILES

CN(C(C=C(N1C)N(CCC2)CCN2C(c(cc2)cc(OC)c2OC)=O)=O)C1=O

InChI

InChI=1S/C20H26N4O5/c1-21-17(13-18(25)22(2)20(21)27)23-8-5-9-24(11-10-23)19(26)14-6-7-15(28-3)16(12-14)29-4/h6-7,12-13H,5,8-11H2,1-4H3

InChI Key

PUCBXHGNPQNPBG-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27246307

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

402.45

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

0.743

Distribution Coefficient, logD

0.743

Water Solubility, LogSw

-1.56

Polar Surface Area

67.772

Acid Dissociation Constant (pKa)

27.80

Base Dissociation Constant (pKb)

-1.36

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

45.00

L329-0490 in Drug Discovery

Included in Screening Libraries

Hsp90-Targeted Library (11355 compounds)

Protein-Protein Interaction Library (218420 compounds)

Recognition Elements PPI Library (24135 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Immune system
Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics

References: we are preparing a list of scientific research reports with L329-0490 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L329-0490?
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What is the minimum amount of L329-0490 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L329-0490
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L329-0490
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L329-0490 available by request