L337-0507 Screening compound: 3-{5-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-1,3,4-thiadiazol-2-yl}-1-(3,5-dimethoxyphenyl)urea

L337-0507 Screening compound: 3-{5-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-1,3,4-thiadiazol-2-yl}-1-(3,5-dimethoxyphenyl)urea
L337-0507 Screening compound: 3-{5-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-1,3,4-thiadiazol-2-yl}-1-(3,5-dimethoxyphenyl)urea alternative view

Chemical Structure Depiction of ChemDiv screening compound L337-0507
3-{5-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-1,3,4-thiadiazol-2-yl}-1-(3,5-dimethoxyphenyl)urea

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L337-0507

Molecular Formula

C21H21N5O4S (C21 H21 N5 O4 S)

Compound Name

3-{5-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-1,3,4-thiadiazol-2-yl}-1-(3,5-dimethoxyphenyl)urea

IUPAC name

3-{5-[2-(23-dihydro-1H-indol-1-yl)-2-oxoethyl]-134-thiadiazol-2-yl}-1-(35-dimethoxyphenyl)urea

SMILES

COc1cc(NC(Nc2nnc(CC(N(CC3)c4c3cccc4)=O)s2)=O)cc(OC)c1

InChI

InChI=1S/C21H21N5O4S/c1-29-15-9-14(10-16(11-15)30-2)22-20(28)23-21-25-24-18(31-21)12-19(27)26-8-7-13-5-3-4-6-17(13)26/h3-6,9-11H,7-8,12H2,1-2H3,(H2,22,23,25,28)

InChI Key

RIAHCEYNGAQIKO-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27247094

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

439.5

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

9.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

4.048

Distribution Coefficient, logD

4.048

Water Solubility, LogSw

-4.16

Polar Surface Area

86.821

Acid Dissociation Constant (pKa)

10.27

Base Dissociation Constant (pKb)

0.44

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

23.80

L337-0507 in Drug Discovery

Included in Screening Libraries

PPI Inhibitors Tripeptide Mimetics (23972 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Targeted Diversity Library (40567 compounds)

Peptidomimetic Library (37031 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics
  • Mimetics
Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with L337-0507 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L337-0507?
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What is the minimum amount of L337-0507 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L337-0507
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L337-0507
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L337-0507 available by request