L378-0364 Screening compound: 4-[1-(3-ethylphenyl)-1H-1,2,3,4-tetrazol-5-yl]-N-(3-fluoro-4-methylphenyl)piperazine-1-carboxamide

L378-0364 Screening compound: 4-[1-(3-ethylphenyl)-1H-1,2,3,4-tetrazol-5-yl]-N-(3-fluoro-4-methylphenyl)piperazine-1-carboxamide
L378-0364 Screening compound: 4-[1-(3-ethylphenyl)-1H-1,2,3,4-tetrazol-5-yl]-N-(3-fluoro-4-methylphenyl)piperazine-1-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L378-0364
4-[1-(3-ethylphenyl)-1H-1,2,3,4-tetrazol-5-yl]-N-(3-fluoro-4-methylphenyl)piperazine-1-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L378-0364

Molecular Formula

C21H24FN7O (C21 H24 FN7 O)

Compound Name

4-[1-(3-ethylphenyl)-1H-1,2,3,4-tetrazol-5-yl]-N-(3-fluoro-4-methylphenyl)piperazine-1-carboxamide

IUPAC name

4-[1-(3-ethylphenyl)-1H-1234-tetrazol-5-yl]-N-(3-fluoro-4-methylphenyl)piperazine-1-carboxamide

SMILES

CCc1cccc(-n2nnnc2N(CC2)CCN2C(Nc2cc(F)c(C)cc2)=O)c1

InChI

InChI=1S/C21H24FN7O/c1-3-16-5-4-6-18(13-16)29-20(24-25-26-29)27-9-11-28(12-10-27)21(30)23-17-8-7-15(2)19(22)14-17/h4-8,13-14H,3,9-12H2,1-2H3,(H,23,30)

InChI Key

GEISQXJCKQNDJV-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15125879

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

409.47

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

4.232

Distribution Coefficient, logD

4.232

Water Solubility, LogSw

-4.18

Polar Surface Area

67.849

Acid Dissociation Constant (pKa)

12.02

Base Dissociation Constant (pKb)

1.34

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

33.30

L378-0364 in Drug Discovery

Included in Screening Libraries

Bcl2-PPI Inhibitors Library (12246 compounds)

Serine Proteases Inhibitors Library (32732 compounds)

SmartTM Library (51161 compounds)

Targeted Diversity Library (40567 compounds)

Inhibitors of beta-Catenin Signaling (7445 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Hemic and lymphatic
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Cardiovascular
  • Skin
  • Metabolic
  • Immune system
Mechanism of action:
  • PPI modulators
Targets:
  • Proteases

References: we are preparing a list of scientific research reports with L378-0364 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L378-0364?
Check Price and Availability of L378-0364, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L378-0364 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L378-0364
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L378-0364
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L378-0364 available by request