L421-2220 Screening compound: 2-{4-[6-methyl-1-phenyl-3-(thiophen-2-yl)-1H,6H-pyrrolo[2,3-c]pyrazole-5-carbonyl]piperazin-1-yl}pyrimidine

L421-2220 Screening compound: 2-{4-[6-methyl-1-phenyl-3-(thiophen-2-yl)-1H,6H-pyrrolo[2,3-c]pyrazole-5-carbonyl]piperazin-1-yl}pyrimidine
L421-2220 Screening compound: 2-{4-[6-methyl-1-phenyl-3-(thiophen-2-yl)-1H,6H-pyrrolo[2,3-c]pyrazole-5-carbonyl]piperazin-1-yl}pyrimidine alternative view

Chemical Structure Depiction of ChemDiv screening compound L421-2220
2-{4-[6-methyl-1-phenyl-3-(thiophen-2-yl)-1H,6H-pyrrolo[2,3-c]pyrazole-5-carbonyl]piperazin-1-yl}pyrimidine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L421-2220

Molecular Formula

C25H23N7OS (C25 H23 N7 OS)

Compound Name

2-{4-[6-methyl-1-phenyl-3-(thiophen-2-yl)-1H,6H-pyrrolo[2,3-c]pyrazole-5-carbonyl]piperazin-1-yl}pyrimidine

IUPAC name

2-{4-[6-methyl-1-phenyl-3-(thiophen-2-yl)-1H6H-pyrrolo[23-c]pyrazole-5-carbonyl]piperazin-1-yl}pyrimidine

SMILES

Cn(c(C(N(CC1)CCN1c1ncccn1)=O)c1)c2c1c(-c1cccs1)nn2-c1ccccc1

InChI

InChI=1S/C25H23N7OS/c1-29-20(24(33)30-12-14-31(15-13-30)25-26-10-6-11-27-25)17-19-22(21-9-5-16-34-21)28-32(23(19)29)18-7-3-2-4-8-18/h2-11,16-17H,12-15H2,1H3

InChI Key

FHTLCVWEBJZWTI-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27251572

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

469.57

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

4.084

Distribution Coefficient, logD

4.084

Water Solubility, LogSw

-4.13

Polar Surface Area

56.408

Acid Dissociation Constant (pKa)

21.08

Base Dissociation Constant (pKb)

2.67

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

20.00

L421-2220 in Drug Discovery

Included in Screening Libraries

Protein Kinases Inhibitors Library (36801 compounds)

SmartTM Library (51161 compounds)

Akt-Targeted Library (14764 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Kinases
  • Kinases

References: we are preparing a list of scientific research reports with L421-2220 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L421-2220?
Check Price and Availability of L421-2220, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L421-2220 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L421-2220
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L421-2220
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L421-2220 available by request