L428-0357 Screening compound: N-(3,5-difluorophenyl)-5-(4-methylphenyl)nicotinamide

L428-0357 Screening compound: N-(3,5-difluorophenyl)-5-(4-methylphenyl)nicotinamide
L428-0357 Screening compound: N-(3,5-difluorophenyl)-5-(4-methylphenyl)nicotinamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L428-0357
N-(3,5-difluorophenyl)-5-(4-methylphenyl)nicotinamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L428-0357

Molecular Formula

C19H14F2N2O (C19 H14 F2 N2 O)

Compound Name

N-(3,5-difluorophenyl)-5-(4-methylphenyl)nicotinamide

IUPAC name

N-(35-difluorophenyl)-5-(4-methylphenyl)pyridine-3-carboxamide

SMILES

Cc(cc1)ccc1-c1cc(C(Nc2cc(F)cc(F)c2)=O)cnc1

InChI

InChI=1S/C19H14F2N2O/c1-12-2-4-13(5-3-12)14-6-15(11-22-10-14)19(24)23-18-8-16(20)7-17(21)9-18/h2-11H,1H3,(H,23,24)

InChI Key

ZPGJYDYITFHAEA-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27252254

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

324.33

Hydrogen Bond Acceptors Count

3.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

3

Partition Coefficient, logP

4.695

Distribution Coefficient, logD

4.485

Water Solubility, LogSw

-4.32

Polar Surface Area

32.666

Acid Dissociation Constant (pKa)

7.61

Base Dissociation Constant (pKb)

2.66

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

5.26

L428-0357 in Drug Discovery

Included in Screening Libraries

Targeted Diversity Library (40567 compounds)

Therapeutical Diversity Annotated Library (7563 compounds)

Voltage-Gated Ion Channel-Targeted Library (4740 compounds)

Akt-Targeted Library (14764 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Ion Channels
  • Kinases

References: we are preparing a list of scientific research reports with L428-0357 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L428-0357?
Check Price and Availability of L428-0357, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L428-0357 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L428-0357
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L428-0357
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L428-0357 available by request