L457-0103 Screening compound: 1-(4-fluorophenyl)-4-[1-(pyridin-4-yl)piperidine-4-carbonyl]piperazine

L457-0103 Screening compound: 1-(4-fluorophenyl)-4-[1-(pyridin-4-yl)piperidine-4-carbonyl]piperazine
L457-0103 Screening compound: 1-(4-fluorophenyl)-4-[1-(pyridin-4-yl)piperidine-4-carbonyl]piperazine alternative view

Chemical Structure Depiction of ChemDiv screening compound L457-0103
1-(4-fluorophenyl)-4-[1-(pyridin-4-yl)piperidine-4-carbonyl]piperazine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L457-0103

Molecular Formula

C21H25FN4O (C21 H25 FN4 O)

Compound Name

1-(4-fluorophenyl)-4-[1-(pyridin-4-yl)piperidine-4-carbonyl]piperazine

IUPAC name

1-(4-fluorophenyl)-4-[1-(pyridin-4-yl)piperidine-4-carbonyl]piperazine

SMILES

O=C(C(CC1)CCN1c1ccncc1)N(CC1)CCN1c(cc1)ccc1F

InChI

InChI=1S/C21H25FN4O/c22-18-1-3-19(4-2-18)25-13-15-26(16-14-25)21(27)17-7-11-24(12-8-17)20-5-9-23-10-6-20/h1-6,9-10,17H,7-8,11-16H2

InChI Key

DHPNHXURAXXUOD-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15128003

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

368.45

Hydrogen Bond Acceptors Count

3.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

2.587

Distribution Coefficient, logD

1.982

Water Solubility, LogSw

-2.36

Polar Surface Area

33.028

Acid Dissociation Constant (pKa)

22.83

Base Dissociation Constant (pKb)

7.88

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

42.90

L457-0103 in Drug Discovery

Included in Screening Libraries

CNS BBB Library (22607 compounds)

CNS Targets (44014 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Protein-Protein Interaction Library (218420 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Ion Channels Focused Library (26372 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
  • Nervous system
  • Cardiovascular
Mechanism of action:
  • PPI modulators
Structure:
  • Cyclic compounds
Targets:
  • Ion Channels

References: we are preparing a list of scientific research reports with L457-0103 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L457-0103?
Check Price and Availability of L457-0103, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L457-0103 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L457-0103
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L457-0103
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L457-0103 available by request