L483-0451 Screening compound: 1-(3-cyano-6-fluoroquinolin-4-yl)-N-(3,4-difluorophenyl)piperidine-4-carboxamide

L483-0451 Screening compound: 1-(3-cyano-6-fluoroquinolin-4-yl)-N-(3,4-difluorophenyl)piperidine-4-carboxamide
L483-0451 Screening compound: 1-(3-cyano-6-fluoroquinolin-4-yl)-N-(3,4-difluorophenyl)piperidine-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L483-0451
1-(3-cyano-6-fluoroquinolin-4-yl)-N-(3,4-difluorophenyl)piperidine-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L483-0451

Molecular Formula

C22H17F3N4O (C22 H17 F3 N4 O)

Compound Name

1-(3-cyano-6-fluoroquinolin-4-yl)-N-(3,4-difluorophenyl)piperidine-4-carboxamide

IUPAC name

1-(3-cyano-6-fluoroquinolin-4-yl)-N-(34-difluorophenyl)piperidine-4-carboxamide

SMILES

N#Cc(cnc(c1c2)ccc2F)c1N(CC1)CCC1C(Nc(cc1)cc(F)c1F)=O

InChI

InChI=1S/C22H17F3N4O/c23-15-1-4-20-17(9-15)21(14(11-26)12-27-20)29-7-5-13(6-8-29)22(30)28-16-2-3-18(24)19(25)10-16/h1-4,9-10,12-13H,5-8H2,(H,28,30)

InChI Key

MWIRCYNNEJUTJA-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27643603

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

410.4

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

3.908

Distribution Coefficient, logD

3.866

Water Solubility, LogSw

-3.99

Polar Surface Area

52.089

Acid Dissociation Constant (pKa)

8.40

Base Dissociation Constant (pKb)

4.25

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

22.70

L483-0451 in Drug Discovery

Included in Screening Libraries

Human GPCR Annotated Library (5539 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Selective Target Activity Profiling Library (14702 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Hemic and lymphatic
  • Cardiovascular
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with L483-0451 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L483-0451?
Check Price and Availability of L483-0451, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L483-0451 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L483-0451
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L483-0451
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L483-0451 available by request