L500-1265 Screening compound: 2-(1-{[4-(5-cyclobutyl-1,2,4-oxadiazol-3-yl)thiophen-2-yl]sulfonyl}piperidine-4-carbonyl)-1,2,3,4-tetrahydroisoquinoline

L500-1265 Screening compound: 2-(1-{[4-(5-cyclobutyl-1,2,4-oxadiazol-3-yl)thiophen-2-yl]sulfonyl}piperidine-4-carbonyl)-1,2,3,4-tetrahydroisoquinoline
L500-1265 Screening compound: 2-(1-{[4-(5-cyclobutyl-1,2,4-oxadiazol-3-yl)thiophen-2-yl]sulfonyl}piperidine-4-carbonyl)-1,2,3,4-tetrahydroisoquinoline alternative view

Chemical Structure Depiction of ChemDiv screening compound L500-1265
2-(1-{[4-(5-cyclobutyl-1,2,4-oxadiazol-3-yl)thiophen-2-yl]sulfonyl}piperidine-4-carbonyl)-1,2,3,4-tetrahydroisoquinoline

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L500-1265

Molecular Formula

C25H28N4O4S2 (C25 H28 N4 O4 S2)

Compound Name

2-(1-{[4-(5-cyclobutyl-1,2,4-oxadiazol-3-yl)thiophen-2-yl]sulfonyl}piperidine-4-carbonyl)-1,2,3,4-tetrahydroisoquinoline

IUPAC name

2-(1-{[4-(5-cyclobutyl-124-oxadiazol-3-yl)thiophen-2-yl]sulfonyl}piperidine-4-carbonyl)-1234-tetrahydroisoquinoline

SMILES

O=C(C(CC1)CCN1S(c1cc(-c2noc(C3CCC3)n2)cs1)(=O)=O)N(CC1)Cc2c1cccc2

InChI

InChI=1S/C25H28N4O4S2/c30-25(28-11-8-17-4-1-2-5-20(17)15-28)19-9-12-29(13-10-19)35(31,32)22-14-21(16-34-22)23-26-24(33-27-23)18-6-3-7-18/h1-2,4-5,14,16,18-19H,3,6-13,15H2

InChI Key

FPTHLKSVLTZGAH-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27458593

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

512.65

Hydrogen Bond Acceptors Count

10.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

4.240

Distribution Coefficient, logD

4.240

Water Solubility, LogSw

-4.24

Polar Surface Area

81.207

Acid Dissociation Constant (pKa)

22.79

Base Dissociation Constant (pKb)

-2.07

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

48.00

L500-1265 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

PPI Inhibitors Tripeptide Mimetics (23972 compounds)

Peptidomimetic Library (37031 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics
  • Mimetics

References: we are preparing a list of scientific research reports with L500-1265 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L500-1265?
Check Price and Availability of L500-1265, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L500-1265 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L500-1265
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L500-1265
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L500-1265 available by request