M136-0153 Screening compound: 1-(1-{3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]pyridin-2-yl}piperidine-4-carbonyl)piperidine-4-carboxamide

M136-0153 Screening compound: 1-(1-{3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]pyridin-2-yl}piperidine-4-carbonyl)piperidine-4-carboxamide
M136-0153 Screening compound: 1-(1-{3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]pyridin-2-yl}piperidine-4-carbonyl)piperidine-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound M136-0153
1-(1-{3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]pyridin-2-yl}piperidine-4-carbonyl)piperidine-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

M136-0153

Molecular Formula

C25H27ClN6O3 (C25 H27 ClN6 O3)

Compound Name

1-(1-{3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]pyridin-2-yl}piperidine-4-carbonyl)piperidine-4-carboxamide

IUPAC name

1-(1-{3-[3-(3-chlorophenyl)-124-oxadiazol-5-yl]pyridin-2-yl}piperidine-4-carbonyl)piperidine-4-carboxamide

SMILES

NC(C(CC1)CCN1C(C(CC1)CCN1c(nccc1)c1-c1nc(-c2cccc(Cl)c2)no1)=O)=O

InChI

InChI=1S/C25H27ClN6O3/c26-19-4-1-3-18(15-19)22-29-24(35-30-22)20-5-2-10-28-23(20)31-11-8-17(9-12-31)25(34)32-13-6-16(7-14-32)21(27)33/h1-5,10,15-17H,6-9,11-14H2,(H2,27,33)

InChI Key

ZJZBHNWOLCBGCV-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27498623

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

494.98

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

3.447

Distribution Coefficient, logD

3.437

Water Solubility, LogSw

-3.89

Polar Surface Area

94.785

Acid Dissociation Constant (pKa)

14.92

Base Dissociation Constant (pKb)

5.77

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

40.00

M136-0153 in Drug Discovery

Included in Screening Libraries

GPCR Targeted Library (31838 compounds)

Hsp90-Targeted Library (11355 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Nonpeptide Peptidomimetics PPI Library (18997 compounds)

Protein-Protein Interaction Library (218420 compounds)

Akt-Targeted Library (14764 compounds)

SH2 PTB Focused Library (6188 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Cancer
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Immune system
  • Hemic and lymphatic
  • Cardiovascular
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • GPCR
  • Kinases
Mechanism of action:
  • Receptor's ligands
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics

References: we are preparing a list of scientific research reports with M136-0153 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound M136-0153?
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What is the minimum amount of M136-0153 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for M136-0153
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for M136-0153
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of M136-0153 available by request