M143-0708 Screening compound: 2-{[7-(4-methoxyphenyl)pyrimido[4,5-d][1,3]diazin-4-yl]sulfanyl}-1-(4-phenylpiperazin-1-yl)ethan-1-one

M143-0708 Screening compound: 2-{[7-(4-methoxyphenyl)pyrimido[4,5-d][1,3]diazin-4-yl]sulfanyl}-1-(4-phenylpiperazin-1-yl)ethan-1-one
M143-0708 Screening compound: 2-{[7-(4-methoxyphenyl)pyrimido[4,5-d][1,3]diazin-4-yl]sulfanyl}-1-(4-phenylpiperazin-1-yl)ethan-1-one alternative view

Chemical Structure Depiction of ChemDiv screening compound M143-0708
2-{[7-(4-methoxyphenyl)pyrimido[4,5-d][1,3]diazin-4-yl]sulfanyl}-1-(4-phenylpiperazin-1-yl)ethan-1-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

M143-0708

Molecular Formula

C25H24N6O2S (C25 H24 N6 O2 S)

Compound Name

2-{[7-(4-methoxyphenyl)pyrimido[4,5-d][1,3]diazin-4-yl]sulfanyl}-1-(4-phenylpiperazin-1-yl)ethan-1-one

IUPAC name

2-{[7-(4-methoxyphenyl)pyrimido[45-d][13]diazin-4-yl]sulfanyl}-1-(4-phenylpiperazin-1-yl)ethan-1-one

SMILES

COc(cc1)ccc1-c1ncc2c(SCC(N(CC3)CCN3c3ccccc3)=O)ncnc2n1

InChI

InChI=1S/C25H24N6O2S/c1-33-20-9-7-18(8-10-20)23-26-15-21-24(29-23)27-17-28-25(21)34-16-22(32)31-13-11-30(12-14-31)19-5-3-2-4-6-19/h2-10,15,17H,11-14,16H2,1H3

InChI Key

YPTDFBKCFBEUTQ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27532317

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

472.57

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

3.918

Distribution Coefficient, logD

3.918

Water Solubility, LogSw

-3.88

Polar Surface Area

66.967

Acid Dissociation Constant (pKa)

18.34

Base Dissociation Constant (pKb)

5.55

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

24.00

M143-0708 in Drug Discovery

Included in Screening Libraries

ACE2 Library (3043 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

CORONAVIRUS Library (20774 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Protein-Protein Interaction Library (218420 compounds)

Akt-Targeted Library (14764 compounds)

Chemokine Receptor-Targeted Library (18382 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Antiviral
  • Infections
  • Immune system
  • Antiviral
  • Infections
  • Immune system
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Immune system
Targets:
  • Kinases
  • Kinases
Mechanism of action:
  • PPI modulators
  • Receptor's ligands

References: we are preparing a list of scientific research reports with M143-0708 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound M143-0708?
Check Price and Availability of M143-0708, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of M143-0708 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for M143-0708
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for M143-0708
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of M143-0708 available by request