P742-0743 Screening compound: 1'-[(3,5-dimethylisoxazol-4-yl)sulfonyl]-1-methylspiro[indole-3,4'-piperidin]-2(1H)-one

P742-0743 Screening compound: 1'-[(3,5-dimethylisoxazol-4-yl)sulfonyl]-1-methylspiro[indole-3,4'-piperidin]-2(1H)-one
P742-0743 Screening compound: 1'-[(3,5-dimethylisoxazol-4-yl)sulfonyl]-1-methylspiro[indole-3,4'-piperidin]-2(1H)-one alternative view

Chemical Structure Depiction of ChemDiv screening compound P742-0743
1'-[(3,5-dimethylisoxazol-4-yl)sulfonyl]-1-methylspiro[indole-3,4'-piperidin]-2(1H)-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

P742-0743

Molecular Formula

C18H21N3O4S (C18 H21 N3 O4 S)

Compound Name

1'-[(3,5-dimethylisoxazol-4-yl)sulfonyl]-1-methylspiro[indole-3,4'-piperidin]-2(1H)-one

IUPAC name

n/a

SMILES

Cc1noc(C)c1S(N(CC1)CCC1(c(cccc1)c1N1C)C1=O)(=O)=O

InChI

InChI=1S/C18H21N3O4S/c1-12-16(13(2)25-19-12)26(23,24)21-10-8-18(9-11-21)14-6-4-5-7-15(14)20(3)17(18)22/h4-7H,8-11H2,1-3H3

InChI Key

ZIXCFAQIANSGAG-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD28994731

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

375.45

Hydrogen Bond Acceptors Count

9.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

2.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

1.291

Distribution Coefficient, logD

1.291

Water Solubility, LogSw

-2.35

Polar Surface Area

69.222

Acid Dissociation Constant (pKa)

26.39

Base Dissociation Constant (pKb)

-1.37

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

44.40

P742-0743 in Drug Discovery

Included in Screening Libraries

Antiviral Library (67538 compounds)

BRD4 Targeted Library (4534 compounds)

Bcl2-PPI Inhibitors Library (12246 compounds)

Bromodomain Modulators Library (5801 compounds)

CNS MPO Library (28609 compounds)

DGK Inhibitors Library (10558 compounds)

GPCR Targeted Library (31838 compounds)

Indole Derivatives (10091 compounds)

PPI Helix Turn 3D-Mimetics Library (71298 compounds)

Protein-Protein Interaction Library (218420 compounds)

Spiro Library (21655 compounds)

Anti-HIV1 Library (19540 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

MDM2-p53 interaction inhibitors Library (21687 compounds)

MEF2-HDAC (class II) Modulators Library (5147 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Antiviral
  • Infections
  • Immune system
  • Cancer
  • Hemic and lymphatic
  • Cardiovascular
  • Metabolic
  • Cancer
  • Hemic and lymphatic
  • Nervous system
  • Cancer
  • Digestive system
  • Hemic and lymphatic
  • Skin
  • Metabolic
  • Immune system
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Antiviral
  • Infections
  • Immune system
  • Cancer
  • Cancer
  • Musculoskeletal
  • Female
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • Others
  • Kinases
  • GPCR
Mechanism of action:
  • PPI modulators
  • Receptor's ligands
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • Epigenetic
Structure:
  • Cyclic compounds
  • Mimetics
  • Cyclic compounds
  • Cyclic compounds

References: we are preparing a list of scientific research reports with P742-0743 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound P742-0743?
Check Price and Availability of P742-0743, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of P742-0743 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for P742-0743
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for P742-0743
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of P742-0743 available by request