T143-0089 Screening compound: 3-[3-(3-fluorophenyl)-1-methyl-4-(pyrrolidin-1-yl)-1H-pyrazol-5-yl]-1-(3-methylphenyl)urea

T143-0089 Screening compound: 3-[3-(3-fluorophenyl)-1-methyl-4-(pyrrolidin-1-yl)-1H-pyrazol-5-yl]-1-(3-methylphenyl)urea
T143-0089 Screening compound: 3-[3-(3-fluorophenyl)-1-methyl-4-(pyrrolidin-1-yl)-1H-pyrazol-5-yl]-1-(3-methylphenyl)urea alternative view

Chemical Structure Depiction of ChemDiv screening compound T143-0089
3-[3-(3-fluorophenyl)-1-methyl-4-(pyrrolidin-1-yl)-1H-pyrazol-5-yl]-1-(3-methylphenyl)urea

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

T143-0089

Molecular Formula

C22H24FN5O (C22 H24 FN5 O)

Compound Name

3-[3-(3-fluorophenyl)-1-methyl-4-(pyrrolidin-1-yl)-1H-pyrazol-5-yl]-1-(3-methylphenyl)urea

IUPAC name

3-[3-(3-fluorophenyl)-1-methyl-4-(pyrrolidin-1-yl)-1H-pyrazol-5-yl]-1-(3-methylphenyl)urea

SMILES

Cc1cccc(NC(Nc(n(C)nc2-c3cccc(F)c3)c2N2CCCC2)=O)c1

InChI

InChI=1S/C22H24FN5O/c1-15-7-5-10-18(13-15)24-22(29)25-21-20(28-11-3-4-12-28)19(26-27(21)2)16-8-6-9-17(23)14-16/h5-10,13-14H,3-4,11-12H2,1-2H3,(H2,24,25,29)

InChI Key

KLNYSYMUPHRQPA-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD31973644

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

393.46

Hydrogen Bond Acceptors Count

3.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

4.757

Distribution Coefficient, logD

4.757

Water Solubility, LogSw

-4.55

Polar Surface Area

50.191

Acid Dissociation Constant (pKa)

12.00

Base Dissociation Constant (pKb)

0.85

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

27.27

T143-0089 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Aurora A-B Kinases Targeted Library (9426 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Male
  • Female
  • Hemic and lymphatic
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with T143-0089 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound T143-0089?
Check Price and Availability of T143-0089, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of T143-0089 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for T143-0089
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for T143-0089
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of T143-0089 available by request