T501-1443 Screening compound: 1-(3-methyl-1H-indazol-1-yl)-4-{3-[(4-phenyl-4H-1,2,4-triazol-3-yl)methyl]piperidin-1-yl}butane-1,4-dione

T501-1443 Screening compound: 1-(3-methyl-1H-indazol-1-yl)-4-{3-[(4-phenyl-4H-1,2,4-triazol-3-yl)methyl]piperidin-1-yl}butane-1,4-dione
T501-1443 Screening compound: 1-(3-methyl-1H-indazol-1-yl)-4-{3-[(4-phenyl-4H-1,2,4-triazol-3-yl)methyl]piperidin-1-yl}butane-1,4-dione alternative view

Chemical Structure Depiction of ChemDiv screening compound T501-1443
1-(3-methyl-1H-indazol-1-yl)-4-{3-[(4-phenyl-4H-1,2,4-triazol-3-yl)methyl]piperidin-1-yl}butane-1,4-dione

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

T501-1443

Molecular Formula

C26H28N6O2 (C26 H28 N6 O2)

Compound Name

1-(3-methyl-1H-indazol-1-yl)-4-{3-[(4-phenyl-4H-1,2,4-triazol-3-yl)methyl]piperidin-1-yl}butane-1,4-dione

IUPAC name

1-(3-methyl-1H-indazol-1-yl)-4-{3-[(4-phenyl-4H-124-triazol-3-yl)methyl]piperidin-1-yl}butane-14-dione

SMILES

Cc1nn(C(CCC(N2CC(Cc3nncn3-c3ccccc3)CCC2)=O)=O)c2c1cccc2

InChI

InChI=1S/C26H28N6O2/c1-19-22-11-5-6-12-23(22)32(29-19)26(34)14-13-25(33)30-15-7-8-20(17-30)16-24-28-27-18-31(24)21-9-3-2-4-10-21/h2-6,9-12,18,20H,7-8,13-17H2,1H3/t20-/m1/s1

InChI Key

IWBLWZYOMJLDNC-HXUWFJFHSA-N

MDL Number (MFCD)

MFCD31972780

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

456.55

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

2.203

Distribution Coefficient, logD

2.203

Water Solubility, LogSw

-2.42

Polar Surface Area

68.674

Acid Dissociation Constant (pKa)

14.83

Base Dissociation Constant (pKb)

4.90

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

34.62

T501-1443 in Drug Discovery

Included in Screening Libraries

PPI Helix Turn 3D-Mimetics Library (71298 compounds)

Protein-Protein Interaction Library (218420 compounds)

Alpha-Helix Mimetics Library (25899 compounds)

Histone Deacetylases (HDAC) Targeted Library (9760 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • Epigenetic
Structure:
  • Mimetics
  • Mimetics
Therapeutical areas:
  • Cancer
  • Nervous system
  • Hemic and lymphatic
  • Endocrine
  • Immune system

References: we are preparing a list of scientific research reports with T501-1443 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound T501-1443?
Check Price and Availability of T501-1443, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of T501-1443 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for T501-1443
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for T501-1443
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of T501-1443 available by request