Z274-0554 Screening compound: 1-[4-(4-chlorophenyl)-2-(2-hydroxyphenyl)-1,5,9-triazaspiro[5.5]undec-1-en-9-yl]ethan-1-one

Z274-0554 Screening compound: 1-[4-(4-chlorophenyl)-2-(2-hydroxyphenyl)-1,5,9-triazaspiro[5.5]undec-1-en-9-yl]ethan-1-one
Z274-0554 Screening compound: 1-[4-(4-chlorophenyl)-2-(2-hydroxyphenyl)-1,5,9-triazaspiro[5.5]undec-1-en-9-yl]ethan-1-one alternative view

Chemical Structure Depiction of ChemDiv screening compound Z274-0554
1-[4-(4-chlorophenyl)-2-(2-hydroxyphenyl)-1,5,9-triazaspiro[5.5]undec-1-en-9-yl]ethan-1-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

Z274-0554

Molecular Formula

C22H24ClN3O2 (C22 H24 ClN3 O2)

Compound Name

1-[4-(4-chlorophenyl)-2-(2-hydroxyphenyl)-1,5,9-triazaspiro[5.5]undec-1-en-9-yl]ethan-1-one

IUPAC name

1-[4-(4-chlorophenyl)-2-(2-hydroxyphenyl)-159-triazaspiro[5.5]undec-1-en-9-yl]ethan-1-one

SMILES

CC(N(CC1)CCC1(NC(C1)c(cc2)ccc2Cl)N=C1c(cccc1)c1O)=O

InChI

InChI=1S/C22H24ClN3O2/c1-15(27)26-12-10-22(11-13-26)24-19(16-6-8-17(23)9-7-16)14-20(25-22)18-4-2-3-5-21(18)28/h2-9,19,24,28H,10-14H2,1H3/t19-/m0/s1

InChI Key

LGEABCXSHGWXSN-IBGZPJMESA-N

MDL Number (MFCD)

MFCD22390612

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

397.9

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

3.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

3.951

Distribution Coefficient, logD

3.928

Water Solubility, LogSw

-4.09

Polar Surface Area

54.723

Acid Dissociation Constant (pKa)

9.57

Base Dissociation Constant (pKb)

6.08

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

36.36

Z274-0554 in Drug Discovery

Included in Screening Libraries

Antiviral HBV Library (10007 compounds)

Hsp90-Targeted Library (11355 compounds)

KRAS-Targeted Library (16000 compounds)

Protein-Protein Interaction Library (218420 compounds)

Serine Proteases Inhibitors Library (32732 compounds)

SmartTM Library (51161 compounds)

Spiro Library (21655 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Ion Channels Focused Library (26372 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Antiviral
  • Infections
  • Immune system
  • Cancer
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Immune system
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Cardiovascular
  • Skin
  • Metabolic
  • Immune system
  • Nervous system
  • Cardiovascular
Targets:
  • Kinases
  • Proteases
  • Ion Channels
Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Cyclic compounds
  • Cyclic compounds

References: we are preparing a list of scientific research reports with Z274-0554 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound Z274-0554?
Check Price and Availability of Z274-0554, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of Z274-0554 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for Z274-0554
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for Z274-0554
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of Z274-0554 available by request