GW274150
Chemical Structure Depiction of
GW274150
GW274150
Compound characteristics
| Compound ID: | CE01-2751 |
| Compound Name: | GW274150 |
| Molecular Weight: | 219.3 |
| Molecular Formula: | C8 H17 N3 O2 S |
| CAS Number: | 210354-22-6 |
| Smiles: | CC(=N)NCCSCC[C@@H](C(O)=O)N |
| InChI Key: | MOLOJNHYNHBPCW-ZETCQYMHSA-N |
| Short Description: | GW274150 is an orally active, selective and potent dual inhibitor of NADPH-dependent human nitric oxide synthase (iNOS) (Kd=40 nM) and rat inducible nitric oxide synthase (iNOS).GW274150 has a low act ivity against endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) in humans and rats. GW274150 showed protective effects in an inflammatory model of acute lung injury. |
| Pathway: | Immunology/Inflammation |
| Target: | NOS |
| Type of molecule: | Clinical |
| Stock amount: | 1524 |