Angiotensin-converting enzyme Library is a set of small-molecule inhibitors of the SARS-CoV-2 binding site.
Neurotransmitter Transporter Inhibitors Library is a set of small-molecule inhibitors. They are used to treat mental disorders.
Antiviral HBV Library is a set of non-nucleoside compounds for HBV treatment.
PTPN Targeted Library is a set of small-molecule inhibitors. Protein tyrosine phosphatases are important signaling molecules in cell proliferation.
Small-molecule compounds that can be used in GPCR drug discovery. Dysregulation of these receptors causes diabetes, CNS disorders.
Protein Kinases Inhibitors Library is modulators that are used in cancer and inflammation treatment.
Ocular Diseases small molecules library covers several ocular diseases: Diabetic Macular Edema (DME), Age-Related Macular Degeneration (AMD), Cataract, Glaucoma.
Ligand-Gated Ion Channels Library is a set of small-molecule compounds that target LGICs. They can be used in the treatment of neurodegenerative disorders.
Carbonic anhydrase II library is a set of compounds belonging to the sulfonamides, mercaptans and phenols aimed at modulating of Carbonic anhydrase II activity
Antiviral Library is a set of small-molecule antiviral agents. These inhibitors target a wide range of viral proteins.
RNA Isosteric Trinucleotide Mimetics is small molecules targeting RNA expansion repeats. Trinucleotide repeats overexpression causes various disorders.
Diacylglycerol kinase Inhibitors Library is a set of small-molecules that can inhibit the progression of cancer and innate cytotoxic immunocytes.
Coronavirus Library (COVID-19) is a set of small-molecule compounds that prevent coronaviral binding and further replication.
Small molecules that can inhibit NOTUM thus potentially treating diseases caused by dysregulation of Wnt signaling.
Set of RAR receptor antagonists. The retinoic acid receptor is a type of nuclear receptor which can also act as a transcription factor.
Antibacterial Compounds Library is a set small-molecule inhibitors of bacterial vital proteins.
Serine Proteases Inhibitors Library is a set of small-molecule compounds that target serine proteases and can be used in anticancer drug discovery.
Proline Kinase Library is a set of kinase inhibitors. These kinases play a crucial role in diverse cellular processes and human diseases.
Molecules from c-Met Library target receptor tyrosine kinase. It prevents binding hepatocyte growth factor with c-Met which can lead to cancer.
Set of small-molecule compounds that can target cysteine proteases and be used in drug development for cancer, viral, infections treatment.
Akt Targeted Library is a set of small-molecule inhibitors of the Akt-signaling network. These inhibitors are widely used in cancer treatment.
PRMT Library is set of small-molecule compounds with reported affinity against cancer-assosiated PRMTs.
Set consists of sp3-enriched β-lactams, generic library of covalent inhibitors, smart library of covalent inhibitors, smart library of covalent fragments.
Androgen Receptor Antagonists Library is a set of non-steroidal small molecules for prostate cancer treatment.
RPTP Targeted Library is small-molecule inhibitors. Disruption of protein tyrosine phosphorylation contributes to a variety of human diseases.
PPI Library is a set of small-molecule modulators that have been designed for disrupting PPI and reducing its drawbacks.
KRAS-Targeted Library is a set of novel KRAS-active compounds.
Nucleoside Mimetics Library is a set of modified nucleosides that are used as antiviral and antitumor drugs. They were also designed for HIV therapy.
Ion Channels Focused Library is small-molecule compounds selected for modulating ion channels proteins. They are therapeutic targets of CNS diseases.
PI3K-Targeted Library is a set of small-molecule inhibitors of PI3K signaling pathway. They can be used in effective inhibiting tumor progression.
Arginase Targeted Library is a set of small-molecule compounds against arginase. This enzyme is implicated in cancer immunosuppression and tumor growth.
Set of small-molecule serine/threonine kinases family inhibitors.
Set of small-molecule HDAC inhibitors. HDAC regulate gene expression and its inhibitors act against cancers, neurodegenerative and inflammatory diseases.
Autophagy-Targeted Library is a set of small-molecule modulators for the regulation of autophagy.
Glucocorticoid Receptors Library is small-molecule selective modulators of GR which regulates gene transcription.
Smart library of covalent inhibitors and fragments with a wide range of reactivity warheads.
PD-1/L1 Library is a set of PD-1 and PD-L1 inhibitors. It is a group of anticancer drugs that block the activity of immune checkpoint proteins.
Anticancer Library is a set of small-molecule compounds with anticancer activity and vast target space.
Epitranscriptome Focused Small Molecule Library modulates the activity of proteins involving in aberrant RNA modification.
Small molecules that mimic the action of peptides thus modulating PPI. Protein secondary structures are targets for mimicry.
Adenosine Receptors Targeted Library is a set of small-molecule ligands. They can be used for treating neurodegeneration diseases.
Recognition Elements PPI Library includes conformationally constrained analogues of bioactive peptides: gamma-, beta-turns, dipeptide mimetics.
3-chymotrypsin-like protease Library is a set of small-molecule compounds for inhibiting coronavirus replication.
Small-molecule compounds that mimic the action of protein and modulates PPI.
MEF2-HDAC (class II) Modulators Library is a set of drug-like compounds aimed at modulating PPI of MEF2 with HDAC involved in physiological processes.
Set of GABA receptor antagonists. These drug-like compounds inhibit the action of GABA and produce stimulant and convulsant effects.
Purinergic Library is a set of purinergic receptor antagonists. Such antagonists are used for thrombosis and stroke treatment.
Papain-like protease Library is a set of drug-like compounds for COVID-19. They inhibit viral replication and the dysregulation of signaling cascades in infected cells.
Set of covalent inhibitors with warheads that target cysteine.
ChemDiv's Crystallographic and 19F NMR fragment libraries contain Fluorine Fragments (1480 compounds) and Bromine Fragments (629 compounds). The fragment library consists of small-molecule compounds containing fluorine or bromine atoms. These fragments are well suited for high throughput screening based on fluorine NMR or X-ray crystallography.
Small‐molecule allosteric kinase modulators that target allosteric pockets of kinases outside the conserved ATP‐binding pocket.
Type II Kinase Inhibitors Library is a set of non-ATP site inhibitors or activators that bind to an extended ATP site including a back pocket.
TLR-8 Ligands Library is a set of small-molecule TLR-8 agonists. They can be used in adjuvantation research and for the treatment of ovarian cancer.
Library contains nonpeptide small-molecules that inhibit PPI. They are structural mimetics to target proteins.
Developmental Pathway Hh/Wnt Set is inhibitors of the Hedgehog and Wnt-signaling pathways implicated in cancer.
Anti-HIV1 Library is a set of anti-HIV1 small-molecule agents for different viral targets.
Purine Based Nucleoside Mimetics Library is nucleoside analogues that mimic metabolic purines. They are extracellular messengers and endogenous modulators.
Bromodomain Modulators Library is a set of drug-like compounds aimed at modulating PPI of bromodomain-containing proteins with other vital proteins.
Antimitotic Tubulin Library is a set of small-molecule tubulin binders. These inhibitors are potential antimitotic drugs for anticancer therapy.
Antifungal Library is a set of small-molecule compounds that target fungi proteins and can be used in antifungal drug development.
Alpha-Helix Mimetics Library is a set of peptidomimetics. Alpha-helices are key recognition elements of protein secondary structure.
CNS MPO Library is a set of drug-likeness designed via Multi-Parameter Optimization for improved BBB-permeability.
Regenerative Medicine Focused Library is a chemical space that includes promoters of regeneration. They help to repair diseased organs or tissues.
Antiparasite Library is a set of small-molecule compounds for drug discovery. It consists of antibacterial, antifungal and insecticide chemicals.
Steroid-like compounds library is steroid-based molecules that regulate biological function. These synthetic steroids can treat inflammation.
MDM2-p53 Interaction Inhibitors Library is a set of drug-like compounds aimed at modulating PPI of MDM2 with p53 involved in tumorigenesis.
Set of small molecules for inhibition of RNA-binding proteins.
Macrocycles Library is a set of macrocyclic peptidomimetics that are potential PPI modulators. It is unique spiro and fused scaffolds.
Heat shock protein 90 Targeted Library is a set of small-molecule modulators that inhibit the activity of HSP90/70 and can be used as anticancer drugs.
BRD4 Targeted Library is a set of small-molecule compounds that inhibit transcriptional and epigenetic regulator - BRD4.
PPI Helix Turn 3D Mimetics Library was designed on sp3-enriched scaffolds that mimic key recognition elements of protein secondary structure.
CNS BBB Library is a set of blood-brain barrier permeable compounds with high chemical diversity and novelty of structures.
Set of small-molecule compounds that inhibit MCL1 thus restoring the apoptotic pathway in tumor cells.
Lipid Metabolism Library is a set of small-molecule modulators of proteins involved in lipid metabolism.
Nucleic Acid Ligands is a set of minor and major groove DNA or RNA binders. Such small molecules have proven to be effective antiviral and cancer agents.
SH2 PTB domains Focused Library is a set of inhibitors. SH2 and PTB are small protein modules that mediate PPIs involved in signal transduction pathways.
Indoleamine 2,3-dioxygenase1 Focused Library is a set of small-molecule compounds that can inhibit inappropriate IDO activity in tumours.
Integrin Receptors Targeted library is a set of RGD peptides or peptidomimetics that affect many events in tumor cells thereby directly induce apoptosis.
Set of PPI modulators. Cyclic lactam amides result from the Ugi reaction of bifunctional keto carboxylic acids.
Anti-infective Library is a set of small-molecule compounds against various infectious agents.
Anti-Aging Library is small molecules targeting cellular pathways and biological targets that are implicated in aging.
Voltage-Gated Ion Channel-Targeted set is small molecule compounds that contribute to treating pain.
Neuropeptide S Library is a set of small-molecule NPSR ligands. They can be used in psychiatric disorders treatment as anxiolytics and analgesics.
Inhibitors of beta-Catenin Signaling is small molecules that target PPI of beta-catenin with other proteins involved in significant physiological processes.
Beyond the Flatland Library sp3-enriched is a set of saturated small-molecules with chemical properties for a faster transition of compounds from discovery to drugs.
Cardiovascular Library is a set of small-molecule compounds with vast target space for cardiovascular disease drug discovery.
3D Mimetics PPI Library is a set of small-molecule compounds that mimic key recognition elements of protein secondary structure.
Anti-Inflammatory Library is a set of small-molecule compounds that target pivotal proteins and receptors participating in the inflammatory process.
Chelators targeting matrix metalloproteinases are small-molecule that inhibit proteolytic activity of tumor cells and prevent metastasis.
PPI Tripeptide Mimetics Library is small-molecule PPI inhibitors that mimic significant endogenous tripeptides.
Bcl2 PPI Inhibitors Library is small molecules that inhibit regulators of programmed cell death.
3D Fragment Library is a set of small-molecule compounds with diverse and well-developed 3D-shapes for HTS and fragment-based drug discovery.
Dark Chemical Matter Library is a set of small-molecules that have never shown biological activity despite having been exhaustively tested in HTS assays.
SH2 Domain Library is a set of inhibitors. SH2 are modular units, which bind to tyrosyl-phosphorylated peptide on their target protein mediating PPI.
Focused Epigenetics Library is a set of small-molecule modulators that target epigenetic proteins.
CNS library is a unique set of small molecule compounds for protein targets relevant for the CNS therapeutic area and neurological related diseases.
STING Agonist Library is small-molecules that bind and activate STING and lead to IFN production. Can be used in cancer immunotherapy.
Natural-Product-Based Library is a set of small-molecule compounds. Natural products have proven successful modulators of difficult targets.
Chemokine Receptor Targeted Library is a set of small-molecule ligands. Modulation of chemokine receptor is used in the treatment of inflammatory diseases.
Spiro Library is a set of scaffolds with twisted structure of two or more rings for the design of new therapeutic agents.
New Agro Library is a set of agrochemicals for usage in crop/agro science.
Eccentric PPI Library is a set of unusual ring systems (scaffolds) that lie outside the field of (hetero)aromatic systems.
Immunological Library is a set of small-molecule compounds that target vast space of proteins involved in immune system.
CNS Targets Library is a set of small-molecule compounds acting on various CNS targets.
Selective small-molecule PDZ inhibitors. They help to overcome drawbacks of PPI.
Fragments Library is a set of small-molecules with high diversity, reduced structural complexity, drug-likeness. They possess a potential for "fragment evolution” and “fragment linking".
Small-molecule compounds that act as antifungals, antibiotics and anti-cancer agents for drug dicsovery.
Frequent Hitters Library is a set of small-molecule compounds that were classified as potentially frequent hitters in high-throughput screening.
Indole Derivatives Library is indole-based compounds. These heterocyclic compounds are active molecules with anti-inflammatory effects.
Macl-GPIb alpha set targets leukocyte-platelet interaction. This leads to an antithrombotic effect.
Angiogenesis Library is a set of small-molecule compounds that target proteins involved in new blood vessels forming.