Arginase Targeted Library

Arginase Targeted Library Arginase Targeted Library Arginase Targeted Library Arginase Targeted Library Arginase Targeted Library Arginase Targeted Library Arginase Targeted Library Arginase Targeted Library Arginase Targeted Library Arginase Targeted Library Arginase Targeted Library Arginase Targeted Library Arginase Targeted Library Arginase Targeted Library Arginase Targeted Library Arginase Targeted Library
Preferred format:
Desirable size of the custom library selection:
Amount:
Mg
  • Mg
  • uMol
Volume:
►Two isoforms in humans Arginase1 (Arg1, cytosol), Arginase2 (Arg2, mitochondria)
►Both catalyze the hydrolysis of L arginine to L ornithine and urea through a mechanism involving one hydroxide and two manganese ions
►Implicated in cancer immunosuppression and cancer tumor growth an increased metabolism of L Arg by myeloid derived suppressor cells producing Arg1 inhibits T lymphocyte response
►Other TIs include the following asthma, erectile dysfunction, cystic fibrosis, and atherosclerosis


►A strong binder is required to displace the hydroxide and replace it in the manganese coordination network
►X Ray structures of arginase cavity indicate a small volume, allowing little structural diversity between the metal coordinating and the amino acid moiety of the ligand
►Almost all the published Arg inhibitors exhibit insufficient differences in affinity to provide isoform selective inhibition in cultured cells or in vivo
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