ADME, DMPK

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DMPK/ADME testing and its influence is important throughout the drug discovery process and is critical to maximizing success. DMPK understanding and application is the link between wanted and unwanted exposure and effect. This knowledge contributes to determining activity against the drug target and target engagement assessment, ensuring an acceptable safety profile, optimizing PK parameters and minimizing drug-drug interaction (DDI) potential. Effective DMPK/ADME studies substantially impact development timelines, project costs and, ultimately, the quality of the molecules progressing to the clinic.

ADME (absorption, distribution, metabolism, and excretion) properties are crucial for understanding the safety and efficacy of a drug candidate, increasing the likelihood of a successful program.

DMPK (drug metabolism and pharmacokinetics) properties of the product determine how much of the drug will reach the target, and the duration it will stay in the target area.

ChemDiv offers standardized and custom programs, led by experienced PhD-level scientific staff.
Our experienced team conducts both in vitro and in vivo studies.

These support the selection of compounds with optimal ADME properties for further development as drug candidates and selection of correct animal species for toxicology studies.

ChemDiv Inc. provides a range of in vitro ADME/T assays to evaluate and improve metabolism, bioavailability, pharmacology, and toxicology characteristics of screening compounds during early stages of hit expansion and lead optimization.

Our researchers develop, validate, and apply different modern methods for the early ADME/T molecular screening of potential drugs under development.

For in vivo studies ChemDiv offers:
  • Pharmacokinetics, tissue distribution, excretion
  • Routes of administration: PO, IM, IP, IV, SC, inhalation, topical
  • In vivo Efficacy Models (CNS, Oncology, Inflammation, etc)
  • Preliminary tox studies (dose-range finding, MTD)
  • Regulatory Toxicity Studies including formulation analysis and toxicokinetics

Animals: mice and rats (in-house), rabbits, dogs, monkeys (with partners)
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