Burger line Burger line Burger line
Logo Logo Logo
Burger line Burger line Burger line
Sign in
Sign in

SH2 Library

Preferred format:
Desirable size of the custom library selection:
  • Mg
  • uMol
ChemDiv’s SH2 Library contains 12,000 compounds.

Src homology 2 (SH2) domains are 100 amino acid modular units, which recognize and bind to tyrosyl-phosphorylated peptide sequences on their target proteins, and thereby mediate intracellular protein-protein interactions.

Currently, more than 50 crystallographic complexes obtained for various small-molecule SH2 domain inhibitors are available within PDB databank. The 4-centered pharmacophore model was constructed based on the selected X-Ray data (2WKM, 3GQL and 4AOI). The reference compounds were then docked into the constructed model starting form 2D structures without any stereo assignment. The obtained results are well correlated with the RSA data used (av. RMSD=0.2).
All the compounds from SH2 domains library were evaluated using the developed pharmacophore model. High-score molecules were included in the library (more than 50% of the total amount).
0
Cart Subtotal:
Go to cart
You will be able to Pay Online or Request a Quote

We use "cookies*  to ensure the functionality of our website, recognise your browser or device, learn more about your interests, and provide you with essential features and services and for additional purposes, including:

Recognising you when you sign-in to use our services. This allows us to provide you with product recommendations, display personalised content, and provide other customised features and services.
Keeping track of your specified preferences. You may set your preferences through Your Account..
Keeping track of items stored in your shopping basket and personal cabinet.
Conducting research and diagnostics to improve ChemDiv’s content, products, and services.
Delivering content, including ads, relevant to your interests on ChemDiv’s site
Reporting. This allows us to measure and analyse the performance of our services.

By  cookies you give consent to the processing of your personal data, including transfer to third parties. Further information can be found in our privacy policy.

Accept all cookies