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Receptor protein tyrosine phosphatases

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  • Mg
  • uMol

ChemDiv’s Receptor-type Protein Tyrosine Phosphatases Targeted Library contains 3,900 compounds.

Protein tyrosine phosphorylation is a fundamental regulatory mechanism controlling cell proliferation, differentiation, communication, and adhesion. Disruption of this key regulatory mechanism contributes to a variety of human diseases including cancer, diabetes, and auto-immune diseases. Net protein tyrosine phosphorylation is determined by the dynamic balance of the activity of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Mammals express many distinct PTKs and PTPs. Both of these families can be sub-divided into non-receptor and receptor subtypes. Receptor-type protein tyrosine phosphatases (RPTPs) are enzymatic and functional counterparts of RPTKs. RPTPs are a family of integral cell surface proteins that possess intracellular PTP activity, and extracellular domains that have sequence homology to cell adhesion molecules. They can bind extracellular ligands, such as growth factors and cytokines. [1]

[1] Y. Xu and G. J. Fisher, “Receptor type protein tyrosine phosphatases (RPTPs) – Roles in signal transduction and human disease,” J. Cell Commun. Signal., vol. 6, no. 3, pp. 125–138, 2012, doi: 10.1007/s12079-012-0171-5.

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