Proteolytic enzymes are crucial for various biological processes in organisms, ranging from lower to higher organisms. Proteases break down proteins into smaller fragments, catalyzing the hydrolysis of peptide bonds. These enzymes are classified according to their catalytic site and are divided into four main classes: cysteine proteases, serine proteases, aspartic proteases and metalloproteases. Protease inhibitors and related enzymes are widely used in medicine and other fields. They are used in the clinic for the treatment of cancer, hypertension, thrombosis, diabetes, as well as viral and bacterial infections.
Protease compound library includes 5 sub libraries:
- Factor XIa
- Factor D
- SaRS-CoV main protease
- Privileged Fragments Approach