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Protease Library

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Protease Library

Our screening library features a diverse range of protease-targeting ligands, designed for drug discovery. Chemical compounds are confirmed to engage with four primary types: cysteine proteases, serine proteases, aspartic proteases, and metalloproteases.

Proteolytic enzymes play a pivotal role in diverse biological processes, facilitating the breakdown of proteins by catalyzing the hydrolysis of peptide bonds. Protease inhibitors and related enzymes find wide-ranging applications in medicine and other fields. They are presumed to be potential drug-like candidates proven to be effective for the therapy of numerous disease areas, including cancer, hypertension, thrombosis, diabetes, and viral and bacterial infections.

Our protease inhibitor screening library contains protease privileged fragment-containing compounds and three separate sub-sets of compounds targeting:

●      Factor XIa

●      Factor D

SaRS-CoV-related proteases

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