CNS Library
Description
ChemDiv’s CNS Library contains 26,000 compounds.A unique collection of small molecule compounds for protein targets relevant for the CNS therapeutic area and neurological related diseases like Parkinson’s disease, Alzheimer’s disease, schizophrenia, drug dependence, etc.
It is patently obvious that CNS activity (and trans-cellular permeability in general) is a complex function of physical/chemical properties of molecules such as size, lipophilicity, hydrogen-bonding potential, charge, and conformation. For any given molecule, one of these factors may dominate others. Drugs with the brain as the site of action should, in general, be able to cross the BBB. Drug delivery to the brain can be enhanced by increasing the lipophilicity of the molecule, by using prodrugs that dissociate after crossing the BBB, or by using passive or active drug targeting that utilizes transport systems at the BBB in the normal or disease states. In general, the transendothelial transport of compounds can depend on binding to constituents of the plasma, ionization state, timedependent plasma concentration, and cerebral flow. It is possible to modify many of these properties with changes in chemical structure. Optimizing the distribution of therapeutic compounds between brain and blood is one of the key issues in the design of novel CNS-active drugs.