Burger line Burger line Burger line
Logo Logo Logo
Burger line Burger line Burger line
Sign in
Sign in

Apoptosis Focused Library

Preferred format:
Desirable size of the custom library selection:
  • Mg
  • uMol

Aberrant apoptosis has been experimentally implicated in a broad variety of illnesses, including AIDS, allograft rejection, restenosis, autoimmunity (lupus, type-I diabetes, rheumatoid arthritis), cancer, heart failure, infectious diseases, inflammation, osteoporosis, trauma and neurodegenerative disorders like Alzheimer’s, Parkinson’s, Huntington’s, ALS, and stroke. Consequently, considerable interest has arisen in therapeutic strategies for modulating apoptosis pharmacologically.

Considering the vast complexity of apoptosis mechanisms, a substantial number of protein targets have been identified and more are likely in the near future. To make matters even more interesting, in certain cases it is desired to preserve cell viability, depending upon discovering anti-apoptotic treatments. In other cases the objective will be to discover pro-apoptosis agents which induce the death of cells that are pathologically resistant. ChemDiv’s collection is divided accordingly with compounds designed for either pro- or anti-apoptosis purposes.

Within our Targeted Diversity Set of focused drug-like libraries biased to apoptotic targets (~20,000 compounds), you will find:

• “Recognition Motifs” Library consisting of peptidomimetics for inhibition of protein- protein interactions (~10,000 compounds)
• Serendipity Library of lead-like fragments (Ro3)/Natural and natural-like compounds (~5,000 compounds)
• Annotated sub-Library Library based on the stem cores (privileged substructures) Sub- sets focused against orthogonal targets (GPCRs, ICh...~5,000 compounds)

In addition, ChemDiv has organized some 30 target-specific sub-libraries (250-750 members each) directed at:

  • Caspase-3(8,9) inhibitors

  • Death associated protein kinase (DAPK) inhibitors 

  • Nerve Growth Factor Receptor LNGFRp75 antagonists

  • Macrophage migration inhibitory factor (MIF) modulators 

  • Cytochrome C inhibitors

  • Mitochondria MPP-pores inhibitors 

  • Phosphatase inhibitors

  • Many more

The selection process for the apoptosis collection involves identifying prototypes existing in the patent and research literature and performing bioisosteric replacement strategies or known small peptide ligands are substituted with heterocyclic peptidomimetics. Then a similarity search is conducted within our own collection for possible augmentation of the rational library. Other techniques include computer-assisted 3-D pharmacophore matching and the synthesis of new heterocyclic chemotypes with functionality mimicking known active “warheads.” In some cases, proof of concept has been established with in-house biological data. 

Every effort is made to insure that the compounds in our collection possess high intellectual property potential as determined by Bielstein and SciFinder substructure searches resulting in a low number of related hits. 

0
Cart Subtotal:
Go to cart
You will be able to Pay Online or Request a Quote

We use "cookies*  to ensure the functionality of our website, recognise your browser or device, learn more about your interests, and provide you with essential features and services and for additional purposes, including:

Recognising you when you sign-in to use our services. This allows us to provide you with product recommendations, display personalised content, and provide other customised features and services.
Keeping track of your specified preferences. You may set your preferences through Your Account..
Keeping track of items stored in your shopping basket and personal cabinet.
Conducting research and diagnostics to improve ChemDiv’s content, products, and services.
Delivering content, including ads, relevant to your interests on ChemDiv’s site
Reporting. This allows us to measure and analyse the performance of our services.

By  cookies you give consent to the processing of your personal data, including transfer to third parties. Further information can be found in our privacy policy.

Accept all cookies