Burger line Burger line Burger line
Logo Logo Logo
Burger line Burger line Burger line
Menu
Sign in
Sign in

Chemokine Receptor-Targeted Library

Preferred format:
Desirable size of the custom library selection:
Amount:
Mg
  • Mg
  • uMol
Volume:
ChemDiv’s Chemokine Receptor-Targeted Library contains 20,000 compounds.

Chemokine receptors – one of the key targets implicated in inflammation diseases, cancer pathology and viral infections. Chemokines are a family of small proteins inducing directed cell migration via specific chemokine receptors, which play important roles in a variety of biological and pathological processes. Therapeutic strategies based on modulation of chemokine receptor pathways were reported to be promising clinical strategies in the treatment of inflammatory diseases, such as multiple sclerosis and atherosclerosis, psoriasis, inflammatory skin diseases and atopic dermatitis, as well as viral infections, including HIV. Chemokine involvement is not limited to immunity and inflammation. Recent studies have clearly demonstrated that chemokines and chemokine receptors are produced by many different cell types, including tumor cells.

Ligand-receptor relationships within the chemokine superfamily are extremely complex. The receptors have been operationally subdivided according to the complexity of their relationships to ligands into various groups. Chemokine receptors, like all members of the GPCR superfamily, mediate signal transduction through specific G-proteins. Although chemokine receptors are morphologically similar to many other 7-TMS receptors, they have several unique structural signatures such as the amino acid sequence DRYLAIV in the second intracellular loop domain.
0 items in Cart
Cart Subtotal:
Go to cart
You will be able to Pay Online or Request a Quote
Catalog
Services
Company

We use "cookies*  to ensure the functionality of our website, recognise your browser or device, learn more about your interests, and provide you with essential features and services and for additional purposes, including:

Recognising you when you sign-in to use our services. This allows us to provide you with product recommendations, display personalised content, and provide other customised features and services.
Keeping track of your specified preferences. You may set your preferences through Your Account..
Keeping track of items stored in your shopping basket and personal cabinet.
Conducting research and diagnostics to improve ChemDiv’s content, products, and services.
Delivering content, including ads, relevant to your interests on ChemDiv’s site
Reporting. This allows us to measure and analyse the performance of our services.

By  cookies you give consent to the processing of your personal data, including transfer to third parties. Further information can be found in our privacy policy.

Accept all cookies