Sugar and sugar-like compound library
ChemDiv’s library of sugars and sugar-like compounds contains 356 entries.
A library of small molecule sugars and sugar-like compounds represents a unique and fertile ground for drug discovery, tapping into the diverse roles that sugars play in biological processes. These compounds can mimic or interfere with the natural sugar molecules involved in various cellular functions, including signaling pathways, cell adhesion, immune responses, and the modulation of protein functions through glycosylation. Our library is instrumental in identifying lead compounds that can act as inhibitors or activators of enzymes involved in carbohydrate metabolism, which is crucial in diseases like diabetes, cancer, and infectious diseases where pathogens rely on sugar metabolism for survival.
Exploring this library can lead to the discovery of novel therapeutics that target the glycome, the ensemble of sugars in an organism, for conditions where aberrant glycosylation patterns play a role, such as in tumor growth and metastasis or in autoimmune diseases. In addition, chemically diverse compounds from our library could be used to inhibit tumor cells' ability to evade the immune system by altering their surface glycosylation patterns. Similarly, in infectious diseases, blocking the interaction between bacterial/viral surface sugars and host receptors could prevent pathogens from entering host cells. Additionally, these compounds could serve as the basis for developing new antiviral drugs by mimicking the sugars that viruses use to attach to and invade host cells. Given the ubiquity of sugars in biological systems, compounds from this library can be applied across a wide array of therapeutic areas, including infectious diseases, oncology, metabolic disorders, and inflammatory conditions. This versatility enhances the potential for breakthroughs in treating diseases with unmet medical needs. The versatility and specificity of sugar and sugar-like molecules offer a broad spectrum of potential therapeutic applications, making this library a valuable resource for drug development efforts aimed at exploiting the subtleties of carbohydrate biology for clinical benefit.
By targeting specific glycosylation pathways and patterns, sugar and sugar-like compounds from our library compounds can pave the way for personalized medicine approaches, particularly in cancer therapy, where individual glycosylation patterns can influence disease progression and treatment response.
Overall, our library of small molecule sugars and sugar-like compounds provides a rich resource for discovering and developing new drugs with the potential for high efficacy and specificity in addressing a range of diseases.