Burger line Burger line Burger line
Logo Logo Logo
Burger line Burger line Burger line
Sign in
Sign in

Natural Product Based Library

Preferred format:
Desirable size of the custom library selection:
  • Mg
  • uMol
ChemDiv’s Natural-Product-Based Library contains 18249 compounds.

Historically, natural products have been pharma’s treasure trove. According to the Natural Products Library Initiative at the Scripps Research Institute, “from 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom.”In a sense, this is not surprising. In nature, after all, creatures – and at the more basic level, structures, such as receptors and their ligands – have been co-evolving for billions of years.

Natural products as well as their derivatives continue to play a significant role in the discovery of new approved therapies, as they have done since the earliest days of medicinal research. Natural products have proven successful modulators of difficult targets such as a range of antibacterial targets and, especially, protein–protein interactions. Furthermore, many researchers consider natural products and their derivatives as a privileged tools for the study and manipulation of protein function.

The library consists of more than 4,000 members belonging 22 scaffolds (average 180 compounds per scaffold). It includes the following sub-libraries:
 Cytisine-based sub-library (approx. 780 cmpnds)
 Matrine-based sub-library (approx. 650 cmpnds)
 Podophyllotoxin-based sub-library (approx. 80 cmpnds)
 Sub-library based on naturally occurring privileged BBs such ashydroxy-prolines,
triptamine, nor-tropinone etc. (approx. 2500 cmpnds)
 The library is a special sub-set of ChemDiv anti-infective and PPI-modulators library biologically relevant chemical space, especially for difficult, traditionally intractable but nevertheless high value targets.
0
Cart Subtotal:
Go to cart
You will be able to Pay Online or Request a Quote

We use "cookies*  to ensure the functionality of our website, recognise your browser or device, learn more about your interests, and provide you with essential features and services and for additional purposes, including:

Recognising you when you sign-in to use our services. This allows us to provide you with product recommendations, display personalised content, and provide other customised features and services.
Keeping track of your specified preferences. You may set your preferences through Your Account..
Keeping track of items stored in your shopping basket and personal cabinet.
Conducting research and diagnostics to improve ChemDiv’s content, products, and services.
Delivering content, including ads, relevant to your interests on ChemDiv’s site
Reporting. This allows us to measure and analyse the performance of our services.

By  cookies you give consent to the processing of your personal data, including transfer to third parties. Further information can be found in our privacy policy.

Accept all cookies