Burger line Burger line Burger line
Logo Logo Logo
Burger line Burger line Burger line
Menu
Sign in
Sign in

NOTUM (Wnt signaling) Library

Preferred format:
Desirable size of the custom library selection:
Amount:
Mg
  • Mg
  • uMol
Volume:

ChemDiv’s NOTUM (Wnt Signaling) Library contains 4,000 compounds.

NOTUM is a carboxylesterase that has been shown to act by mediating the O-depalmitoleoylation of Wnt proteins resulting in suppression of Wnt signaling. Members of the Wnt family are secreted signaling proteins that play key roles in adult stem cell biology as well as in embryonic development. Conversely, dysregulation of Wnt signaling is frequently associated with growth-related pathologies and cancers, particularly those of tissues for which Wnts normally stimulate self-renewal and repair. Wnt signaling is also implicated to have a role in neurodegenerative diseases such as Alzheimer’s disease. O-Palmitoleoylation of a conserved serine residue in Wnt proteins is a key post-translation modification required for efficient binding of Wnt proteins to Frizzled receptors, a requirement for signal transduction. A carboxylesterase NOTUM was previously shown to antagonize Wnt signaling pathways. More recently, NOTUM has been shown to act by mediating the depalmitoleoylation of Wnt proteins resulting in suppression of Wnt signaling. It follows that inhibition of NOTUM could restore Wnt signaling with potential benefit in diseases where Wnt deficiency is an underlying cause. [1]

[1] B. N. Atkinson et al., “Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen,” Medchemcomm, vol. 10, no. 8, pp. 1361–1369, 2019, doi: 10.1039/c9md00096h.

0 items in Cart
Cart Subtotal:
Go to cart
You will be able to Pay Online or Request a Quote
Catalog
Services
Company

We use "cookies*  to ensure the functionality of our website, recognise your browser or device, learn more about your interests, and provide you with essential features and services and for additional purposes, including:

Recognising you when you sign-in to use our services. This allows us to provide you with product recommendations, display personalised content, and provide other customised features and services.
Keeping track of your specified preferences. You may set your preferences through Your Account..
Keeping track of items stored in your shopping basket and personal cabinet.
Conducting research and diagnostics to improve ChemDiv’s content, products, and services.
Delivering content, including ads, relevant to your interests on ChemDiv’s site
Reporting. This allows us to measure and analyse the performance of our services.

By  cookies you give consent to the processing of your personal data, including transfer to third parties. Further information can be found in our privacy policy.

Accept all cookies