Stem Cell Modulators library
Stem Cell Modulators library
Over 21,200 stock available compounds, Comprised by 1105 templates
Design
In assemblying our stem cell modulator library, we took into consideration both pathway analysis as well as the reported ‘singleton’ targets involved in stem cell differentiation. Notably, absolute majority of these data came from work conducted with the induced pluripotent stem cells (iPS’s) and mouse embryonic stem cells (mES’s). An example of logic behind putting together this compound set: IGF1R signaling cascade: all reported key nodules (PDK1, Pi3Ka-g, Akt1-3, GSKb, mTOR) have been analyzed w/regard to their reported involvement in stem cell differentiation (literature), prioritized and assessed w/re to the reported small molecule in- hibitors/modulators. Notably, we targeted compounds with the reported diverse pharmacology against a specific target’. For instance, we were interested in BOTH selective and polypharmacology-based tools (ex., compounds that hit multiple isoforms of PI3K or dual PI3K/mTOR inhibitors). Also, we were interested in ACTIVE SITE and ALLOSTERIC modulators featuring ‘partial’ effect (ex., partial inverse antagonist/agonist). As a result of this effort, we have identified estimated 200 biological targets involved directly or indirectly in the stem cell differentiation and populated our library with reported and suspected modulators of their differentiation and their close analogues in order to yield immediate SAR profile.
Over 21,200 stock available compounds, Comprised by 1105 templates
Design
In assemblying our stem cell modulator library, we took into consideration both pathway analysis as well as the reported ‘singleton’ targets involved in stem cell differentiation. Notably, absolute majority of these data came from work conducted with the induced pluripotent stem cells (iPS’s) and mouse embryonic stem cells (mES’s). An example of logic behind putting together this compound set: IGF1R signaling cascade: all reported key nodules (PDK1, Pi3Ka-g, Akt1-3, GSKb, mTOR) have been analyzed w/regard to their reported involvement in stem cell differentiation (literature), prioritized and assessed w/re to the reported small molecule in- hibitors/modulators. Notably, we targeted compounds with the reported diverse pharmacology against a specific target’. For instance, we were interested in BOTH selective and polypharmacology-based tools (ex., compounds that hit multiple isoforms of PI3K or dual PI3K/mTOR inhibitors). Also, we were interested in ACTIVE SITE and ALLOSTERIC modulators featuring ‘partial’ effect (ex., partial inverse antagonist/agonist). As a result of this effort, we have identified estimated 200 biological targets involved directly or indirectly in the stem cell differentiation and populated our library with reported and suspected modulators of their differentiation and their close analogues in order to yield immediate SAR profile.