Burger line Burger line Burger line
Logo Logo Logo
Burger line Burger line Burger line
Sign in
Sign in

ACE2 Library

Preferred format:
Desirable size of the custom library selection:
  • Mg
  • uMol

ChemDiv’s ACE2 library contains 3,117 compounds.

ACE2 (angiotensin-converting enzyme) is a critical component of the counter-regulatory pathway of the RAAS, that regulators blood pressure, inflammation, and fibrosis and is crucial to the pathophysiology of hypertension, cardiovascular disease, and chronic kidney disease. ACE2 converts Ang II into Ang-(1–7), which lower blood pressure and reduce inflammation and fibrosis. Ang-(1–7)’s primary actions are to promote vasodilation and sodium and water excretion, reduce sympathetic nervous system tone, and increase nitric oxide production.

ACE2 is the SARS-CoV-2 binding site. The unique interaction of SARS-CoV-2 with the host cell is the putative link between COVID-19 and hypertension, cardiovascular disease, and kidney disease. As with SARS-CoV, the SARS-CoV-2 spike protein binds to membrane-bound ACE2 on the surface of respiratory epithelial cells to gain cell entry, although SARS-CoV-2 appears to do so with significantly greater affinity. Endocytosis of the SARS-CoV-2–ACE2 complex, as well as viral-induced ACE2 cell surface shedding and ACE2 downregulation, all may contribute to decreased ACE2 expression and activity in infected cells. This overall loss of ACE2 functionality could be critically important to COVID-19 pathophysiology. [1]

[1] A. M. South, T. M. Brady, and J. T. Flynn, “ACE2 (Angiotensin-Converting Enzyme 2), COVID-19, and ACE Inhibitor and Ang II (Angiotensin II) Receptor Blocker Use During the Pandemic: The Pediatric Perspective,” Hypertens. (Dallas, Tex. 1979), vol. 76, no. 1, pp. 16–22, 2020, doi: 10.1161/HYPERTENSIONAHA.120.15291.

0
Cart Subtotal:
Go to cart
You will be able to Pay Online or Request a Quote

We use "cookies*  to ensure the functionality of our website, recognise your browser or device, learn more about your interests, and provide you with essential features and services and for additional purposes, including:

Recognising you when you sign-in to use our services. This allows us to provide you with product recommendations, display personalised content, and provide other customised features and services.
Keeping track of your specified preferences. You may set your preferences through Your Account..
Keeping track of items stored in your shopping basket and personal cabinet.
Conducting research and diagnostics to improve ChemDiv’s content, products, and services.
Delivering content, including ads, relevant to your interests on ChemDiv’s site
Reporting. This allows us to measure and analyse the performance of our services.

By  cookies you give consent to the processing of your personal data, including transfer to third parties. Further information can be found in our privacy policy.

Accept all cookies