RNA Isosteric Trinucleotide Mimetics Library
RNA Isosteric Trinucleotide Mimetics (rITM) Library – 3D Biodiversity Library, the first principle small molecules library specifically designed for targeting RNA expansion repeats.
It is unique chemistry with strong IP potential, customizable to your specific needs: size, cherry-picking, lead-likeness profiling, format options and delivery options.
Publications•Connelly, C.M. et al. (2017) The Emerging Role of RNA as a Therapeutic Target for Small Molecules. Cell Chem. Biol. 23 (9) 1077-1090.
•Angelbello, A.J. et al. (2018). Using Genome Sequence to Enable the Design of Medicines and Chemical Probes. Chem. Rev. 118 (4), 1599–1663.
•Jain, A. et al. (2017) RNA phase transitions in repeat expansion disorders. Nature 546 (7657) 243-247.
•Rossi, S. et al. (2015) Nuclear accumulation of mRNAs underlies G4C2‐repeat‐induced translational repression in a cellular model of C9orf72 ALS. J. Cell Sci. 128, 1787-1799.
•Berry-Kravis, E.M. (2018) Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome. Nat. Rev. Drug Discov. 17 (4), 280-299.
•Rizvi, N.F. (2017) RNA as a small molecule druggable target. Bioorg. & Med. Chem. Lett. 27 (23), 5083–5088.
•Liang, X. et al. (2016) Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames. Nature Biotechnology 34, 875–880.
•Eddy, S.R. (2014) Computational Analysis of Conserved RNA Secondary Structure in Transcriptomes and Genomes. Annual Review of Biophysics 43, 433-456.