Burger line Burger line Burger line
Logo Logo Logo
Burger line Burger line Burger line
Sign in
Sign in

Indoleamine 2,3-dioxygenase 1 Focused Library

Preferred format:
Desirable size of the custom library selection:
  • Mg
  • uMol
ChemDiv’s Indoleamine 2,3-dioxygenase 1 Focused Library contains 6,000 compounds.

Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant, essential amino acid, l-tryptophan, along the kynurenine pathway. The local cellular depletion of l-tryptophan that results may enable the host to inhibit the growth of various infectious pathogens in vivo. However, over the past decade, it has become increasingly apparent that IDO also represents an important immune control enzyme. Thus, cells expressing IDO, are capable of suppressing local T cell responses to promote immune tolerance under various physiological and pathophysiological conditions of medical importance, including infectious diseases, foetal rejection, organ transplantation, neuropathology, inflammatory and auto-immune disorders and cancer.

IDO represents an ideal target for therapeutic intervention. Inhibition of inappropriate IDO activity in tumours in vivo may attenuate the ability of tumours to evade immune surveillance and promote clearance. In neurological disorders characterized by increased levels of the excitatory neurotoxin, quinolinic acid there is considerable interest in the utility of kynurenine-3 mono-oxygenase inhibitors to block the production of quinolinic acid, while increasing kynurenic acid, an antagonist of quinolinic acid toxicity. [1]

[1] N. J. C. King and S. R. Thomas, “Molecules in focus: Indoleamine 2,3-dioxygenase,” Int. J. Biochem. Cell Biol., vol. 39, no. 12, pp. 2167–2172, 2007, doi: 10.1016/j.biocel.2007.01.004.
0
Cart Subtotal:
Go to cart
You will be able to Pay Online or Request a Quote

We use "cookies*  to ensure the functionality of our website, recognise your browser or device, learn more about your interests, and provide you with essential features and services and for additional purposes, including:

Recognising you when you sign-in to use our services. This allows us to provide you with product recommendations, display personalised content, and provide other customised features and services.
Keeping track of your specified preferences. You may set your preferences through Your Account..
Keeping track of items stored in your shopping basket and personal cabinet.
Conducting research and diagnostics to improve ChemDiv’s content, products, and services.
Delivering content, including ads, relevant to your interests on ChemDiv’s site
Reporting. This allows us to measure and analyse the performance of our services.

By  cookies you give consent to the processing of your personal data, including transfer to third parties. Further information can be found in our privacy policy.

Accept all cookies