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miRNA targeted small molecule library

miRNA targeted small molecule library miRNA targeted small molecule library miRNA targeted small molecule library miRNA targeted small molecule library miRNA targeted small molecule library miRNA targeted small molecule library miRNA targeted small molecule library miRNA targeted small molecule library
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Description

MicroRNAs (miRs) are small (~18e25 nucleotides), noncoding RNAs, involved in regulation of cell division, proliferation, and death.

MiRs can have a role in a wide range of diseases including cancer, neurologic disorders, autoimmune diseases, metabolic diseases, and cardiovascular diseases.

Since their discovery in 1993, over 2500 human mature miRs have been found; their mechanism of action and functions are focus for the ongoing research [1, 2].

Despite the fact that numerous small molecules have been discovered over the last decade, research into miR targeted small molecules has just started. We share CheDiv's miR-targeted library in hope to help this field continue to thrive. 

Publications

  1. Alles J, Fehlmann T, Fischer U, Backes C, Galata V, Minet M, Hart M, Abu-Halima M, Grässer FA, Lenhof HP, Keller A, Meese E. An estimate of the total number of true human miRNAs. Nucleic Acids Res. 2019 Apr 23;47(7):3353-3364. doi: 10.1093/nar/gkz097


  2. Van Meter EN, Onyango JA, Teske KA. A review of currently identified small molecule modulators of microRNA function. Eur J Med Chem. 2020 Feb 15;188:112008. doi: 10.1016/j.ejmech.2019.112008



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