Factor XIa Compounds Library
DescriptionChemDiv’s Factor XIa Targeted Library contains ~6,500 compounds.
Currently, all FDA-approved anticoagulants have an extensive list of side effects, the most of which are related to bleeding.
The coagulation cascade is the most prevalent target for these drugs. It contains two major pathways:
• the extrinsic pathway – initiated by endothelium damage or hypoxia
• the intrinsic pathway – triggered by damage to blood vessel
Clinical evidences suggest that selectively inhibiting the latter could lessen the risks of bleeding.
Factor XIa (FXIa – plasma thromboplastin antecedent) is a serine protease of the intrinsic pathway. This protein is involved in the amplification of procoagulation signal amplification. As a result, it is an attractive target for the treatment of thrombotic disorders.
This library of carefully selected virtual hits can serve as the foundation for developing a new anticoagulant with a mode of action focused at inhibiting Factor XIa.