Burger line Burger line Burger line
Logo Logo Logo
Burger line Burger line Burger line
Menu
Sign in
Sign in

Voltage-Gated Ion Channel-Targeted Library

Preferred format:
Desirable size of the custom library selection:
Amount:
Mg
  • Mg
  • uMol
Volume:

Voltage-Gated Ion Channel-Targeted Library contains 5,000 compounds.  

Voltage-gated ion channels were among the first ion channels to be identified. Voltage-gated ion channels contain sequence motifs that are necessary for their targeting, because these sequences may mediate interactions with proteins that are directly or indirectly involved with channel binding. Voltage-gated ion channels are formed by either one α-subunit that is a contiguous polypeptide that contains four repeats (domains I–IV) or four α-subunits, each with a single domain. [1] Sodium channels are closed and inactive at rest but undergo structural changes in response to membrane depolarization, leading to cycling of the channel through activated (open), inactive, and repriming states.

It is recognized that pain is a complex perception, which depends on electrical activity within sensory neurons. Within these neurons, voltage-gated sodium channels assist the generation and conduction of action potentials. This pivotal role of sodium channels in electrogenesis has made them attractive targets for pharmacotherapeutic approaches aimed at attenuating neuronal firing that result in pain. It was shown that even specific sodium channel isoforms are major contributors to chronic pain. Sodium channels can be modulated by a variety of small molecule pharmacological agents. Many of the clinically relevant modulators, such as lidocaine and carbamazepine, exhibit pronounced state-dependent binding where sodium channels that are rapidly and repeatedly activated and inactivated are easier blocked. [2]

[1]         H. C. Lai and L. Y. Jan, “The distribution and targeting of neuronal voltage-gated ion channels,” Nat. Rev. Neurosci., vol. 7, no. 7, pp. 548–562, 2006, doi: 10.1038/nrn1938.

[2]         S. D. Dib-Hajj, J. A. Black, and S. G. Waxman, “Voltage-gated sodium channels: Therapeutic targets for pain,” Pain Med., vol. 10, no. 7, pp. 1260–1269, 2009, doi: 10.1111/j.1526-4637.2009.00719.x.

0 items in Cart
Cart Subtotal:
Go to cart
You will be able to Pay Online or Request a Quote
Catalog
Services
Company

We use "cookies*  to ensure the functionality of our website, recognise your browser or device, learn more about your interests, and provide you with essential features and services and for additional purposes, including:

Recognising you when you sign-in to use our services. This allows us to provide you with product recommendations, display personalised content, and provide other customised features and services.
Keeping track of your specified preferences. You may set your preferences through Your Account..
Keeping track of items stored in your shopping basket and personal cabinet.
Conducting research and diagnostics to improve ChemDiv’s content, products, and services.
Delivering content, including ads, relevant to your interests on ChemDiv’s site
Reporting. This allows us to measure and analyse the performance of our services.

By  cookies you give consent to the processing of your personal data, including transfer to third parties. Further information can be found in our privacy policy.

Accept all cookies