Regenerative Medicine Focused Library

Description

The Regenerative Medicine Focused Library from ChemDiv is a specialized collection of 23,032 compounds specifically curated for research in regenerative medicine. This field of medicine aims to develop methods to regrow, repair, or replace damaged or diseased cells, organs, or tissues. The library's goal is to support, stimulate, and enhance the body's natural healing capabilities and assist in repairing defects that would not normally heal on their own.

This library is particularly significant in the context of autologous approaches to therapy, where patients' own cells are used to stimulate regeneration. It has shown success in promoting accelerated healing in joints and spinal discs, offering potential relief from pain, restoration of function, and possibly avoiding the need for surgery. The compounds included in this library play a crucial role in this aspect of medical research, providing a valuable resource for developing new treatments that leverage the body's inherent regenerative capacities.

Our library is pre-filtered for its potential to impact regeneration, allowing you to focus on the most promising leads. The library's diverse range of compounds is instrumental in the exploration of novel therapeutic avenues in regenerative medicine, marking it as an essential tool for researchers and scientists working in this transformative area of healthcare.

Examples of the library clusters and main chemical features of compounds offered by this library are provided in a slide deck above, which is freely available for download.

Publications

[1] The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly.

Sidrauski et al. eLife 2015; 4:e05033. DOI: 10.7554/eLife.05033

[2] Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury. Chou et al. PNAS

2017; 114 (31) E6420-E6426. DOI: 10.1073/pnas.1707661114

[3] Experimental Evidence Shows Salubrinal, an eIF2α Dephosphorylation Inhibitor, Reduces Xenotoxicant-Induced

Cellular Damage. Matsuoka M. et al. Int. J. Mol. Sci. 2015; 16, 16275-16287. DOI: 10.3390/ijms16071627.

[4] Safety of Nicergoline as an Agent for Management of Cognitive Function Disorders. Saletu B. et al. BioMed Research

International 2014; Article ID 610103, 6 pages. DOI: 10.1155/2014/610103.

[5] Natural Cognitive Enhancers. Tabassum N. et al. Journal of Pharmacy Research 2012; 5(1),153-160.

[6] Proteins and small molecules for cellular regenerative medicine. Green E.M. et al. Physiol Rev. 2013; 93(1):311-25.

DOI: 10.1152/physrev.00005.2012.

[7] Small Molecules Targeting in Vivo Tissue Regeneration. Längle D. et al. ACS Chem. Biol. 2014; 9, 57−71. DOI:

10.1021/cb4008277.

[8] Small molecules and small molecule drugs in regenerative medicine. Lu B. et al. Drug Discovery Today 2013; 19(6),

801-808. DOI: 10.1016/j.drudis.2013.11.011.

[9] Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Shkhyan R.

et al. Ann Rheum Dis 2018; 0:1–10. DOI: 10.1136/annrheumdis-2017-212037.

[10] Re-education begins at home: an overview of the discovery of in vivo-active small molecule modulators of endogenous

stem cells. Um J. et al. Expert Opinion on Drug Discovery 2018; 20 pages. DOI: 10.1080/17460441.2018.1437140.

[11] ChEMBL database version ChEMBL25 https://www.ebi.ac.uk/chembl/ 

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