Burger line Burger line Burger line
Logo Logo Logo
Burger line Burger line Burger line
Sign in
Sign in

Adenosine Receptors Targeted Library

Preferred format:
Desirable size of the custom library selection:
  • Mg
  • uMol

ChemDiv’s Adenosine Receptors Targeted Library contains 21,000 compounds.

It is well known that adenosine is an important intermediary metabolite, acting as a building block for nucleic acids and a component of the biological energy currency ATP. In addition, adenosine functions as a signalling molecule through the activation of four distinct adenosine receptors — denoted A1, A2A, A2B and A3. These receptors are widely expressed and have been implicated in several biological functions, both physiological and pathological. These include cardiac rhythm and circulation, lipolysis, renal blood flow, immune function, sleep regulation and angiogenesis, as well as inflammatory diseases, ischaemia-reperfusion and neurodegenerative disorders.

The possibility of therapeutically targeting adenosine receptors is clear and has been so for a long time. Selective adenosine receptor agonists and antagonists are available and several trials are currently in progress. The greatest challenge in developing adenosine receptor ligands for specific clinical applications is that adenosine signalling is so widespread. Adenosine itself is present ubiquitously, adenosine receptors are widely distributed throughout the body. [1]

[1] Chen, J.-F., Eltzschig, H. K., & Fredholm, B. B. (2013). Adenosine receptors as drug targets — what are the challenges? Nature Reviews Drug Discovery, 12(4), 265–286. doi:10.1038/nrd3955

0
Cart Subtotal:
Go to cart
You will be able to Pay Online or Request a Quote

We use "cookies*  to ensure the functionality of our website, recognise your browser or device, learn more about your interests, and provide you with essential features and services and for additional purposes, including:

Recognising you when you sign-in to use our services. This allows us to provide you with product recommendations, display personalised content, and provide other customised features and services.
Keeping track of your specified preferences. You may set your preferences through Your Account..
Keeping track of items stored in your shopping basket and personal cabinet.
Conducting research and diagnostics to improve ChemDiv’s content, products, and services.
Delivering content, including ads, relevant to your interests on ChemDiv’s site
Reporting. This allows us to measure and analyse the performance of our services.

By  cookies you give consent to the processing of your personal data, including transfer to third parties. Further information can be found in our privacy policy.

Accept all cookies