INT-777
Chemical Structure Depiction of
INT-777
INT-777
Compound characteristics
| Compound ID: | CE01-2912 |
| Compound Name: | INT-777 |
| Molecular Weight: | 450.66 |
| Molecular Formula: | C27 H46 O5 |
| CAS Number: | 1199796-29-6 |
| Smiles: | [H][C@]12C[C@@H](CC[C@]2(C)[C@@]2([H])C[C@@H]([C@@]3(C)[C@@]([H])(CC[C@]3([H])[C@H](C)C[C@H](C)C(O)=O)[C@]2([H])[C@@H]([C@@H]1CC)O)O)O |
| InChI Key: | NPBCMXATLRCCLF-DSFCAUQDSA-N |
| Short Description: | INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 muM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachno id hemorrhage in rats. |
| Pathway: | GPCR/G Protein |
| Target: | GPCR19 |
| Alias: | S-EMCA |
| Stock amount: | 393 |