Delgocitinib
Chemical Structure Depiction of
Delgocitinib
Delgocitinib
Compound characteristics
| Compound ID: | CE01-9124 |
| Compound Name: | Delgocitinib |
| Molecular Weight: | 310.36 |
| Molecular Formula: | C16 H18 N6 O |
| CAS Number: | 1263774-59-9 |
| Smiles: | C[C@H]1CN(C(CC#N)=O)[C@]12CCN(C2)c1c2cc[nH]c2ncn1 |
| InChI Key: | LOWWYYZBZNSPDT-BZNIZROVSA-N |
| Short Description: | Delgocitinib (Corectim(Delgocitinib)) is a potent and specific JAK inhibitor with an IC50 value of 2.8, 2.6, 13 and 58 nM against JAK1, JAK2, JAK3 and Tyk2. Delgocitinib is involved in a variety of in flammatory and autoimmune diseases through JAK-dependent cytokines and can be widely used in the treatment of various inflammatory diseases. Delgocitinib is the world's first JAK topical compound for the treatment of atopic dermatitis. |
| Pathway: | Angiogenesis|||JAK/STAT signaling|||Stem Cells|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic |
| Target: | JAK|||Tyrosine Kinases |
| Type of molecule: | Approved/Clinical |
| Alias: | JTE-052 , Corectim(Delgocitinib) |
| Stock amount: | 2220 |