LP-935509
Chemical Structure Depiction of
LP-935509
LP-935509
Compound characteristics
| Compound ID: | CE01-9844 |
| Compound Name: | LP-935509 |
| Molecular Weight: | 396.45 |
| Molecular Formula: | C20 H24 N6 O3 |
| CAS Number: | 1454555-29-3 |
| Smiles: | CC(C)OC(N1CCN(CC1)c1ccn2c(c(cn2)c2cccnc2OC)n1)=O |
| InChI Key: | GOOYSJIWTIHOGW-UHFFFAOYSA-N |
| Short Description: | LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of cyclin G-associated kinase(GAK, IC50=320 nM). LP-935509 is also a ATP-competitive inhibitor of adapter protein-2 associated kinase 1 (AAK1) (IC50 = 3.3 nM, Ki = 0.9 nM). |
| Pathway: | Cell Cycle/Checkpoint|||Metabolism|||Neuroscience |
| Target: | AAK1 (AP2 associated kinase 1)|||Serine/threonin kinase |
| Stock amount: | 835 |