Apitolisib

Chemical Structure Depiction of
Apitolisib
Pack Size, mg
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Compound characteristics

Compound ID: CE02-3282
Compound Name: Apitolisib
Molecular Weight: 498.61
Molecular Formula: C23 H30 N8 O3 S
CAS Number: 1032754-93-0
Smiles: Cc1c2c(c(nc(c3cnc(N)nc3)n2)N2CCOCC2)sc1CN1CCN(CC1)C([C@H](C)O)=O
InChI Key: YOVVNQKCSKSHKT-HNNXBMFYSA-N
Short Description: Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kalpha(IC50=5 nM), PI3Kbeta(IC50=27 nM), PI3Kdelta(IC50=7 nM), PI3Kgamma (IC50=14 nM), is used in trials study of solid cancers, breas t cancer, prostate cancer, renal cell carcinoma, and endometrial carcinoma, among others.
Pathway: Apoptosis|||PI3K/Akt/mTOR signaling
Target: Apoptosis|||PI3K|||mTOR
Type of molecule: Clinical
Alias: RG 7422 , GNE 390 , GDC-0980
Stock amount: 1086
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