Lexibulin
Chemical Structure Depiction of
Lexibulin
Lexibulin
Compound characteristics
| Compound ID: | CE02-4945 |
| Compound Name: | Lexibulin |
| Molecular Weight: | 434.54 |
| Molecular Formula: | C24 H30 N6 O2 |
| CAS Number: | 917111-44-5 |
| Smiles: | CCC[C@@H](c1cccnc1)Nc1c(C)cnc(c2ccc(c(c2)OC)NC(NCC)=O)n1 |
| InChI Key: | MTJHLONVHHPNSI-IBGZPJMESA-N |
| Short Description: | Lexibulin (CYT-997)(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death. |
| Pathway: | Cytoskeletal Signaling|||Metabolism|||NF-Kappab|||Immunology/Inflammation|||Apoptosis |
| Target: | Microtubule Associated|||Apoptosis|||Reactive Oxygen Species |
| Type of molecule: | Clinical |
| Alias: | CYT-997 |
| Stock amount: | 646 |