Lifirafenib
Chemical Structure Depiction of
Lifirafenib
Lifirafenib
Compound characteristics
| Compound ID: | CE02-5986 |
| Compound Name: | Lifirafenib |
| Molecular Weight: | 478.43 |
| Molecular Formula: | C25 H17 F3 N4 O3 |
| CAS Number: | 1446090-79-4 |
| Smiles: | [H][C@@]12[C@@H](c3nc4ccc(cc4[nH]3)C(F)(F)F)[C@]1([H])c1cc(ccc1O2)OC1C=CNC2C=1CCC(N=2)=O |
| InChI Key: | NGFFVZQXSRKHBM-BHIFYINESA-N |
| Short Description: | Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L85 8R mutant respectively. |
| Pathway: | JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors|||MAPK |
| Target: | Raf|||EGFR |
| Type of molecule: | Clinical |
| Alias: | BGB-283 , Beigene-283 |
| Stock amount: | 472 |