PF-6274484
Chemical Structure Depiction of
PF-6274484
PF-6274484
Compound characteristics
| Compound ID: | CE02-6107 |
| Compound Name: | PF-6274484 |
| Molecular Weight: | 372.78 |
| Molecular Formula: | C18 H14 Cl F N4 O2 |
| CAS Number: | 1035638-91-5 |
| Smiles: | COc1cc2c(cc1NC(C=C)=O)c(Nc1ccc(c(c1)[Cl])F)ncn2 |
| InChI Key: | TUYDDIWQXWTNSW-UHFFFAOYSA-N |
| Short Description: | PF-6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively. |
| Pathway: | Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis |
| Target: | EGFR |
| Alias: | PF 6274484 |
| Stock amount: | 1037 |