RO8994
Chemical Structure Depiction of
RO8994
RO8994
Compound characteristics
| Compound ID: | CE03-9562 |
| Compound Name: | RO8994 |
| Molecular Weight: | 613.52 |
| Molecular Formula: | C31 H31 Cl2 F N4 O4 |
| CAS Number: | 1309684-94-3 |
| Smiles: | CC(C)(C)C[C@H]1[C@@]2(C(Nc3cc(ccc23)[Cl])=O)[C@@H](c2cccc(c2F)[Cl])[C@H](C(Nc2ccc(cc2OC)C(N)=O)=O)N1 |
| InChI Key: | MURAVORBGFDSMA-JAMCOLSMSA-N |
| Short Description: | RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays). |
| Pathway: | Apoptosis|||Ubiquitination |
| Target: | E1/E2/E3 Enzyme|||p53|||Mdm2 |
| Stock amount: | 934 |